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| Naloxone hydrochloride dihydrate Basic information |
| Naloxone hydrochloride dihydrate Chemical Properties |
| Melting point | 182 °C (dec.)(lit.) | | storage temp. | 2-8°C | | solubility | ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light. | | form | powder | | color | white to off-white | | optical activity | [α]25/D 178.6°, c = 2.5 in H2O(lit.) | | Merck | 13,6388 | | BRN | 6260807 | | CAS DataBase Reference | 51481-60-8(CAS DataBase Reference) |
| Naloxone hydrochloride dihydrate Usage And Synthesis |
| Chemical Properties | White or almost white, hygroscopic, crystalline powder. | | Uses | Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist. | | Uses | Antagonist (to narcotics). | | Brand name | Narcan (Bristol-Myers Squibb); Narcan (Endo). | | Biochem/physiol Actions | Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema. | | Purification Methods | This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.] |
| Naloxone hydrochloride dihydrate Preparation Products And Raw materials |
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