4'-CHLOROACETANILIDE

CAS No.：539-03-7

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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4'-CHLOROACETANILIDE Basic information

Product Name:	4'-CHLOROACETANILIDE
Synonyms:	ACETIC ACID 4-CHLOROANILIDE;ACETAMINOPHEN IMPURITY J;ACETAMINOPHENE IMP J;4'-CHLOROACETANILIDE;4-CHLOROACETANILIDE;4-CHLORACETANILIDE;LABOTEST-BB LT00792311;P-CHLOROACETANILIDE
CAS:	539-03-7
MF:	C8H8ClNO
MW:	169.61
EINECS:	208-707-8
Product Categories:	Amines;Aromatics;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Anilines, Amides & Amines;Chlorine Compounds
Mol File:	539-03-7.mol

4'-CHLOROACETANILIDE Chemical Properties

Melting point	176-178 °C(lit.)
Boiling point	333 °C
density	1,385 g/cm³
refractive index	1.5670 (estimate)
Fp	333°C
storage temp.	2-8°C
solubility	dioxane: 50 mg/mL hot, clear
pka	14.25±0.70(Predicted)
form	Crystalline Powder
color	White or grayish-beige
Water Solubility	Insoluble in water.
Merck	14,2111
BRN	509638
CAS DataBase Reference	539-03-7(CAS DataBase Reference)
EPA Substance Registry System	4-Chloroacetanilide (539-03-7)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	AE1001000
TSCA	Yes
HS Code	29242990
Hazardous Substances Data	539-03-7(Hazardous Substances Data)

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

4'-CHLOROACETANILIDE Usage And Synthesis

Chemical Properties	white or greyish-beige crystalline powder
Uses	4'-Chloroacetanilide is used in pharmaceutical preparations, using PGC column. And also used in the synthesis of alprazolam.
Definition	ChEBI: Acetamide substituted on nitrogen by a para-chlorophenyl group.
Synthesis Reference(s)	Tetrahedron, 52, p. 8863, 1996 DOI: 10.1016/0040-4020(96)00433-4
General Description	4′-Chloroacetanilide is the main impurity present in acetaminophen and has been quantitated by new high-performance liquid chromatography method using a mixed-mode reversed-phase/cation exchange stationary phase.
Purification Methods	Crystallise the anilide from EtOH or aqueous EtOH. [Beilstein 12 IV 1178.]

4'-CHLOROACETANILIDE Preparation Products And Raw materials

Preparation Products

N-(2-AMINO-4-CHLOROPHENYL)ANTHRANILIC ACID-->Ethanone,1-(2-amino-5-chlorophenyl)--->2,6-DICHLORO-1,4-BENZOQUINONE-->2'-Chloroacetanilide-->5-Chloroorthanilic acid

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