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| AURINTRICARBOXYLIC ACID Basic information |
| Product Name: | AURINTRICARBOXYLIC ACID | | Synonyms: | Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem;1,4-cyclohexadiene-1-carboxylicacid,3-(bis(3-carboxy-4-hydroxyphenyl)methylen;5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-benzoicaci;aluminonfreeacid;e)-6-oxo-;5,5'-((3-Carboxy-4-oxocyclohexa-2,5-dien-1-ylidene);bis(2-hydroxybenzoic acid);TIMTEC-BB SBB005410 | | CAS: | 4431-00-9 | | MF: | C22H14O9 | | MW: | 422.34 | | EINECS: | 224-628-1 | | Product Categories: | Colours, Dyes, Indicators & Pigments | | Mol File: | 4431-00-9.mol |
| AURINTRICARBOXYLIC ACID Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | GU4790000 | | TSCA | Yes |
| AURINTRICARBOXYLIC ACID Usage And Synthesis |
| Chemical Properties | deep red coarse crystalline powder | | Uses | endonuclease inhibitor; apoptosis inhibitor, topoisomerase II inhibitor | | Uses | Aurintricarboxylic acid is employed as a powerful inhibitor of cellular processes, including apoptosis, that are dependent on the formation of protein-nucleic acid complexes. It binds to a FGF and reduces its angiogenic activity. Aurintricarboxylic Acid has been shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. It Inhibits protein-nucleic acid interactions. It stimulates the tyrosine phosphorylation of MAP kinases. | | Definition | ChEBI: A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while
the triammonium salt is 'aluminon'. | | Purification Methods | The acid is dissolved in aqueous NaOH, NaHSO3 solution is added until the colour is discharged and then the tricarboxylic acid is precipitated with HCl. [Heisig & Lauer Org Synth Coll Vol I 54 1941, Beilstein 10 IV 4161]. Do not extract the acid with hot water because it softens, forming a viscous mass. Make a solution in aqueous NH3. Aluminon is the NH4 salt. |
| AURINTRICARBOXYLIC ACID Preparation Products And Raw materials |
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