| 4'-Hydroxy-3'-methylacetophenone Basic information |
| Product Name: | 4'-Hydroxy-3'-methylacetophenone |
| Synonyms: | Ethanone, 1-(4-hydroxy-3-methylphenyl)-;1-(4-HYDROXY-3-METHYLPHENYL)ETHAN-1-ONE;1-(4-HYDROXY-3-METHYLPHENYL)ETHANONE;4-ACETYL-2-METHYLPHENOL;4'-HYDROXY-3'-METHYLACETOPHENONE;4-HYDROXY-3-METHYLACETOPHENONE;3'-Methyl-4'-Hydroxy Acetophenone;4-hydroxy-3-methylphenyl methyl ketone |
| CAS: | 876-02-8 |
| MF: | C9H10O2 |
| MW: | 150.17 |
| EINECS: | 212-880-5 |
| Product Categories: | Building Blocks;Carbonyl Compounds;Aromatic Acetophenones & Derivatives (substituted);Benzene series;Chemical Synthesis;Organic Building Blocks;Benzene derivatives;C9;Carbonyl Compounds;Ketones |
| Mol File: | 876-02-8.mol |
| 4'-Hydroxy-3'-methylacetophenone Chemical Properties |
| Melting point | 107-109 °C(lit.) |
| Boiling point | 175°C 1mm |
| density | 1.0858 (rough estimate) |
| refractive index | 1.5180 (estimate) |
| Fp | 175°C/1mm |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.52±0.18(Predicted) |
| color | Off-White to Pale Beige |
| BRN | 2041839 |
| CAS DataBase Reference | 876-02-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Hydroxy-3-methylacetophenone(876-02-8) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 36/37/39-26-22-37/39 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29143990 |
| MSDS Information |
| Provider | Language |
|---|---|
| 4'-Hydroxy-3'-methylacetophenone | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| 4'-Hydroxy-3'-methylacetophenone Usage And Synthesis |
| Chemical Properties | white to light beige crystalline powder or |
| Uses | 4''-Hydroxy-3''-methylacetophenone is used in the synthesis of 3-De(hydroxymethyl)-3-methyl Salmeterol (D230650), which is an impurity of β2-Adrenergic agonist Salmeterol (S090100). |
| Preparation | Preparation by dealkylation of 4-hydroxy-5-methyl-2-iso-propylacetophenone with aluminium chloride in chloro-benzene at 50° (53%). |
| Synthesis Reference(s) | Journal of Medicinal Chemistry, 23, p. 738, 1980 DOI: 10.1021/jm00181a008 |
| 4'-Hydroxy-3'-methylacetophenone Preparation Products And Raw materials |
| Raw materials | Chlorine-->Dichloroacetyl chloride-->NSC 46633-->O-TOLYL ACETATE-->Acetyl chloride-->o-Cresol-->Acetic acid |
| Preparation Products | Chlorpyrifos-->Chlorpyrifos,E.C. |
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