Product

2-Chloro-4-picoline

CAS No.：3678-62-4

Other grades of this product :

2-Chloro-4-picoline Basic information

Product Name:	2-Chloro-4-picoline
Synonyms:	2-Chlor-4-methylpyridin;2-Chlor2-Chloro-4-picolineo-4-picoline;2-Chloro-4-mehyl pyridine;4-Picoline, 2-chloro-;Pyridine, 2-chloro-4-methyl-;2-CHLORO-GAMMA-PICOLINE;2-CHLOROPICOLINE;2-CHLORO-4-PICOLINE
CAS:	3678-62-4
MF:	C6H6ClN
MW:	127.57
EINECS:	222-951-2
Product Categories:	Pyridine;pyridine derivative;Halides;Chloropyridines;Halopyridines;pyridine series;Pyridines
Mol File:	3678-62-4.mol

2-Chloro-4-picoline Chemical Properties

Melting point	115°C
Boiling point	194-195 °C (lit.)
density	1.142 g/mL at 25 °C (lit.)
refractive index	n20/D 1.529(lit.)
Fp	193 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Liquid
pka	0.94±0.10(Predicted)
Specific Gravity	1.14
color	Clear colorless to light yellow
CAS DataBase Reference	3678-62-4(CAS DataBase Reference)
NIST Chemistry Reference	2-Cl-4-(CH3)-pyridine(3678-62-4)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22
Safety Statements	26-36-36/37/39
WGK Germany	3
HazardClass	IRRITANT, IRRITANT-HARMFUL
HS Code	29349990

MSDS Information

Provider	Language
2-Chloro-4-methylpyridine	English
ACROS	English
SigmaAldrich	English

2-Chloro-4-picoline Usage And Synthesis

Chemical Properties	Colorless to light yellow liquid.
Uses	2-Chloro-4-methylpyridine is used as a reagent in the synthesis of the mGLUR5 modulators imidazolyl-ethynyl-pyridines as potential antipsychotics. It is also used in the preparation of trifluoromethyl(pyrimidinyl)azetidinecarboxamides as potent, orally bioavailable TGR5 agonists.
General Description	2-Chloro-4-methylpyridine (2-Chloro-4-picoline) reacts with 3,5-bis(trifluoromethyl)phenylboronic acid to form 2-(3,5-bis(trifluoromethyl)phenyl)-4-methylpyridine by palladium-catalyzed cross-coupling reaction.

2-Chloro-4-picoline Preparation Products And Raw materials

Preparation Products

2-CYANO-4-METHYLPYRIDINE

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