Product

(R)-3-Hydroxypyrrolidine

CAS No.：2799-21-5

Other grades of this product :

(R)-3-Hydroxypyrrolidine Basic information

Product Name:	(R)-3-Hydroxypyrrolidine
Synonyms:	(3R)-3-PYRROLIDINOL;(3R)-Pyrrolidin-3-ol;R-(+)-3-PYRROLIDINOL 98%;(R)-(+)-3-HYDROXYPYRROLIDINE , EE 99%;(R)-(+)-3-Hydroxypyrrolidine, 99%, ee 99%;(3R)-Pyrrolidine-3-ol;(R)-Pyrrolidine-3-ol;(R)-(+)-3-Pyrrolidinol,98%
CAS:	2799-21-5
MF:	C4H9NO
MW:	87.12
EINECS:	628-839-3
Product Categories:	pharmacetical;API intermediates;Chiral Building Blocks;Simple Alcohols (Chiral);Synthetic Organic Chemistry
Mol File:	2799-21-5.mol

(R)-3-Hydroxypyrrolidine Chemical Properties

Melting point	15°C
alpha	6.5 º (c=3.5% in MeOH)
Boiling point	215-216 °C (lit.)
density	1.078 g/mL at 20 °C (lit.)
refractive index	n20/D 1.488(lit.)
Fp	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Viscous Liquid
pka	14.91±0.20(Predicted)
Specific Gravity	1.048
color	Clear yellow to orange-brown
optical activity	[α]20/D +6.5°, c = 3.5 in methanol
Water Solubility	Soluble in water and methanol.
Sensitive	Air Sensitive & Hygroscopic
BRN	5376132
CAS DataBase Reference	2799-21-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
WGK Germany	3
F	10-34
Hazard Note	Irritant
HS Code	29339900

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

(R)-3-Hydroxypyrrolidine Usage And Synthesis

Chemical Properties	clear yellow to orange-brown viscous liquid
Uses	(R)-Pyrrolidin-3-ol is used in preparation of allosteric BCR-ABL bifunctional proteolysis targeting chimera compounds.
Purification Methods	The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

(R)-3-Hydroxypyrrolidine Preparation Products And Raw materials

Raw materials

Ethyl acetate-->Methanol-->Tetrahydrofuran-->Dichloromethane-->Lithium Aluminum Hydride-->Palladium-->Sodium borohydride-->Xylene-->Benzylamine-->iodine-->D(+)-Malic acid

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