Other grades of this product :
| 2,4-Pyridinedicarboxylic acid Basic information |
| Product Name: | 2,4-Pyridinedicarboxylic acid | | Synonyms: | RARECHEM AL BO 0286;PYRIDINE-2,4-DICARBOXYLIC ACID;LUTIDINIC ACID;2,4-LUTIDINIC ACID;2,4-PYRIDINEDICARBOXYLIC ACID;2,4-Pyridinedicarboxylic acid hydrate;2,4-PyridinecarboxylicAcid;2,4-Pyridinedicarboxylic acid hydrate, 99+% | | CAS: | 499-80-9 | | MF: | C7H5NO4 | | MW: | 167.12 | | EINECS: | 207-892-2 | | Product Categories: | Heterocycle-Pyridine series;Piperidines ,Piperazines ,Homopiperidines | | Mol File: | 499-80-9.mol |
| 2,4-Pyridinedicarboxylic acid Chemical Properties |
| Melting point | 243-246 °C | | Boiling point | 295.67°C (rough estimate) | | density | 1.5216 (rough estimate) | | vapor pressure | 0.001Pa at 25℃ | | refractive index | 1.6280 (estimate) | | storage temp. | Store below +30°C. | | solubility | 2.49g/l | | pka | 2.15(at 25℃) | | form | Crystalline Powder | | color | White to almost white | | Water Solubility | Soluble in water at 20°C 4.5 g/L. | | λmax | 258nm(MeOH aq.)(lit.) | | BRN | 131631 | | LogP | 0.57 | | CAS DataBase Reference | 499-80-9(CAS DataBase Reference) | | EPA Substance Registry System | 2,4-Pyridinedicarboxylic acid (499-80-9) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 24/25-26 | | WGK Germany | 3 | | TSCA | Yes | | HS Code | 29333999 |
| 2,4-Pyridinedicarboxylic acid Usage And Synthesis |
| Chemical Properties | white to almost white crystalline powder | | Uses | 2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target. | | Uses | 2,4-Pyridinedicarboxylic Acid is a jumonji C (JmjC) histone demethylase inhibitor. | | Definition | ChEBI: A pyridinedicarboxylic acid carrying carboxy groups at positions 2 and 4. | | Flammability and Explosibility | Notclassified | | Biological Activity | 2,4-pyridinedicarboxylic acid (2,4-pdca) is an inhibitor of histone lysine-specific demethylases that targets on jmjd2a (kdm4a), kdm4c, kdm4e (ic50, 1.4 μm), kdm5b (ic50, 3 μm), kdm6a and other 2-oxogynases [1][2].histone lysine-specific demethylases jmjd2a (kdm4a) and kdm4c are both members of the jumonji domain 2 (jmjd2) family and function as trimethylation-specific demethylases, converting specific trimethylated histone residues to the dimethylated form. kdm5b is an h3k4me3⁄ me2-specific lysine demethylase [1][2].2,4-pyridinedicarboxylic acid (2,4-pdca) is an inhibitor of jmjd2a (kdm4a), kdm4c and kdm5b. in the fdh-coupled assay, 2,4-pdca inhibited cckdm5b with ic50 value of 3 ± 1 μm. in maldi-tof analysis of h3(1-21)k4me3, 2,4-pdca reduced the level of h3(1-15) induced by cckdm5b. in u2-os cells transfected with kdm5b, 2,4-pdca inhibited the decrease of h3k4me3 [1]. in hg-treated vsmcs, 2,4-pdca (1.0 mm) inhibited jmjd2a and hg-induced proliferation in a concentration-dependent way, and inhibited hg-induced migration. 2,4-pdca also reduced the mrna and protein levels of mcp-1 and il-6 [2].in diabetic rats, 2,4-pdca (7.5 mg/kg/d) reduced neointimal area and i/m ratio in the injured arteries 28 days after injury. 2,4-pdca also inhibited the percentage of pcna-positive cells in the neointima [2]. | | references | [1]. kristensen lh, nielsen al, helgstrand c, et al. studies of h3k4me3 demethylation by kdm5b/jarid1b/plu1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. febs j, 2012, 279(11): 1905-1914. [2]. qi h, jing z, xiaolin w, et al. histone demethylase jmjd2a inhibition attenuates neointimal hyperplasia in the carotid arteries of balloon-injured diabetic rats via transcriptional silencing: inflammatory gene expression in vascular smooth muscle cells. cell physiol biochem, 2015, 37(2): 719-734. |
| 2,4-Pyridinedicarboxylic acid Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye