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| Indole-2-carboxylic acid Basic information |
| Indole-2-carboxylic acid Chemical Properties |
| Melting point | 202-206 °C(lit.) | | Boiling point | 287.44°C (rough estimate) | | density | 1.2480 (rough estimate) | | refractive index | 1.5050 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Soluble in clear yellow solution 5% in ethanol, dimethyl sulfoxide and methanol. | | pka | 4.44±0.30(Predicted) | | form | Crystalline Powder or Crystals | | color | Off-white to yellow to brown | | BRN | 124132 | | CAS DataBase Reference | 1477-50-5(CAS DataBase Reference) | | NIST Chemistry Reference | Indole-2-carboxylic acid(1477-50-5) |
| Hazard Codes | Xn,Xi | | Risk Statements | 36/37/38-21/22 | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | NK7882812 | | HazardClass | IRRITANT | | HS Code | 29339990 |
| Indole-2-carboxylic acid Usage And Synthesis |
| Chemical Properties | Yellow Crystalline Powder | | Uses | • ;Reactant for total synthesis of (±)-dibromophakellin and analogs1• ;Reactant for synthesis of the pyrrolizidine alkaloid (±)-trachelanthamidine2• ;Reactant for stereoselective preparation of renieramycin G analogs3• ;Reactant for preparation of spirooxoindolepyrrolidines via reduction of indole-2-carboxylic acid followed by oxidation, condensation, reduction, amidation and Kharasch radical cyclization4• ;Reactant for Pd-catalyzed cyclization5• ;Reactant for preparation of N,N′-(pentane)diylbis[indolecarboxamide] and N,N′-[phenylenebis( | | Uses | Reactant for total synthesis of (±)-dibromophakellin and analogs, synthesis of the pyrrolizidine alkaloid (±)-trachelanthamidine, stereo selective preparation of renieramycin G analogs, preparation of spirooxoindolepyrrolidines via reduction of indole-2-carboxylic acid followed by oxidation, condensation, reduction, amidation and Kharasch radical cyclization, Pd-catalyzed cyclization and N,N?-(pentane)diylbis[indolecarboxamide] and N,N?-[phenylenebis(methylene)]bis[indolecarboxamide] derivatives. | | Synthesis Reference(s) | Tetrahedron Letters, 33, p. 7961, 1992 DOI: 10.1016/S0040-4039(00)74789-7 |
| Indole-2-carboxylic acid Preparation Products And Raw materials |
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