4-(Aminomethyl)benzoic acid

4-(Aminomethyl)benzoic acid
  • CAS No.:56-91-7
Other grades of this product :
4-(Aminomethyl)benzoic acid Basic information
Description References
Product Name:4-(Aminomethyl)benzoic acid
Synonyms:AMINOMETHYL BENZOIC ACID;H-4-AMB-OH;H-(4)AMBZ-OH;LABOTEST-BB LT00053184;4-CARBOXYBENZYLAMINE;4-(AMINOMETHYL)BENZOIC ACID;RARECHEM AL BW 0005;NH2-CH2-PH(4)-COOH
CAS:56-91-7
MF:C8H9NO2
MW:151.16
EINECS:200-297-9
Product Categories:Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Aromatic Amino Acids;CARBOXYLICACID;Pharmaceutical Raw Materials;Peptide Synthesis;Unnatural Amino Acid Derivatives;Acids and Derivatives;Amines and Anilines
Mol File:56-91-7.mol
4-(Aminomethyl)benzoic acid Chemical Properties
Melting point ≥300 °C (lit.)
Boiling point 273.17°C (rough estimate)
density 1.2023 (rough estimate)
refractive index 1.5810 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Aqueous Base (Slightly), Water (Slightly, Heated, Sonicated)
pka3.75±0.10(Predicted)
form Powder
color White to almost white
Water Solubility Slightly soluble in water. Insoluble in ethanol, benzene and chloroform.
BRN 1100606
Stability:Stable. Incompatible with strong oxidizing agents.
InChIKeyQCTBMLYLENLHLA-UHFFFAOYSA-N
CAS DataBase Reference56-91-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39-26,37/39
WGK Germany 3
HS Code 29224999
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
4-(Aminomethyl)benzoic acid Usage And Synthesis
Description4-(Aminomethyl)benzoic acid is a organic compound that can serve as a type 2 antifibrinolytic agent used in the treatment of fibrotic skin disorders, such as Peyronie's disease. It is believed that 4-(Aminomethyl)benzoic acid is effective to increase the oxygen uptake at the tissue level and enhance activity of monoamine oxidase, thus to promote the degradation of serotonin, which in excess, may lead to fibrotic changes. It is also administrated by mouth to treat several skin conditions including vitiligo, pemphigus, dermatomyositis, morphea, lymphoblastoma cutis and scleroderma. It is sometimes used in pill form by patients suffering from irritable bowel syndrome to treat the relevant gastrointestinal symptoms and applied in nutritional epidemiological studies to assess the completeness of 24-hour urine collection for the determination of urinary sodium, potassium, or nitrogen levels. Besides, it can also serve as nutritional supplements to darken gray hair, prevent hair loss, make skin look younger and prevent sunburn and its benefits are claimed for people with fatigue, irritability, depression, weeping eczema, scleroderma, patchy pigment loss in skin, and premature grey hair.
Referenceshttps://en.wikipedia.org/wiki/4-Aminobenzoic_acid https://www.alfa.com/en/catalog/B23519/ https://pubchem.ncbi.nlm.nih.gov/compound/4-aminobenzoic_acid#section=Top http://www.webmd.com/vitamins-supplements/ingredientmono-1004-PABA+PARA-AMINOBENZOIC+ACID+PABA.aspxactiveIngredientId=1004&activeIngredientName=PABA
Chemical Propertieswhite to light yellow crystal powde
Uses4-(Aminomethyl)benzoic Acid is a type 2 antifibrinolytic agent.
Uses4-(Aminomethyl)benzoic acid acts as an unnatural amino acid derivative. It is also used as a type 2 antifibrinolytic agent. Further, it reacts with 2-methyl-isothiourea sulfate to prepare 4-guanidinomethylbenzoic acid.
Uses4-(Aminomethyl)benzoic acid (PAMBA) can be used in the synthesis of:
  • Cobalt carboxy phosphonates.
  • Apoptozole (Az), which has cellular potency to promote membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel activity.
  • Cyclopeptide composed of L-glutamic acid and 3-aminobenzoic acid that can be used as receptors for a variety of cations and anions.
  • A bioactive peptide which has potent GPR54 (a G protein-coupled receptor) agonistic activity.

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