6-Aminoquinoline

6-Aminoquinoline
  • CAS No.:580-15-4
Other grades of this product :
6-Aminoquinoline Basic information
Product Name:6-Aminoquinoline
Synonyms:6-AQ;Quinolin-6-amine, 6-Amino-1-azanaphthalene;Quinoline, 6-amino- (8CI);TIMTEC-BB SBB004130;QUINOLINE, 6-AMINO-;QUINOLIN-6-AMINE;QUINOLIN-6-YLAMINE;6-QUINOLINAMINE
CAS:580-15-4
MF:C9H8N2
MW:144.17
EINECS:209-453-0
Product Categories:Aminoquinolines;Quinolines;Quinolines, Quinazolines and derivatives;API intermediates
Mol File:580-15-4.mol
6-Aminoquinoline Chemical Properties
Melting point 115-119 °C (lit.)
Boiling point 146 °C/0.3 mmHg (lit.)
density 1.1148 (estimate)
refractive index 1.7080 (estimate)
Fp 146°C/0.3mm
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform, DMSO, Methanol
form Solid
pkapK1: 5.63(+1) (20°C,μ=0.01)
color Pale Brown to Brown
Water Solubility Soluble in methanol, chloroform, ethanol, and benzene. Insoluble in water.
Sensitive Air Sensitive
BRN 113320
CAS DataBase Reference580-15-4(CAS DataBase Reference)
NIST Chemistry Reference6-Quinolinamine(580-15-4)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/38-36/37/38-20/21/22
Safety Statements 26-36-36/37/39
RIDADR 2811
WGK Germany 3
2-10
HazardClass IRRITANT, AIR SENSITIVE
PackingGroup III
HS Code 29334900
MSDS Information
ProviderLanguage
6-Aminoquinoline English
SigmaAldrich English
ACROS English
ALFA English
6-Aminoquinoline Usage And Synthesis
Chemical PropertiesDark yellow to brown crystalline powder
Uses6-Aminoquinoline is used in the preparation of diaminopyrimidine derivatives as 5-HT4 receptor agonists.
Uses6-Aminoquinoline was used as an internal standard in determining serum nicotine and cotinine simultaneously by using high-performance liquid chromatography (HPLC)-fluorometric detection with a postcolumn ultraviolet-photoirradiation system. It was also used as a fluorescent derivatizing agent for the detection of biochemicals and in the synthesis of tertiary N-methylated enaminonesa.
Purification MethodsIt is purified by column chromatography on a SiO2 column using CHCl3/MeOH (4:1) as eluent. It crystallises from *C6H6 or *C6H6/pet ether and is an irritant. The styphnate has m 239-240o (from EtOH) and m 242-243o (from aqueous Me2CO). [Barrett et al. J Chem Soc 50, 57 1953, Beilstein 22 III/IV 4681, 22/10 V 303.]
6-Aminoquinoline Preparation Products And Raw materials
Raw materialsIodine-->Glycerol-->4-Nitroaniline-->Activated carbon,decolor-->Ammonium sulfide-->6-NITROQUINOLINE
Preparation Products6-Iodoquinoline

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