PELITINIB

CAS No.：257933-82-7

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PELITINIB Basic information

Product Name:	PELITINIB
Synonyms:	PELITINIB;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;WAY-EKB 569;PELITINIB (EKB-569;WAY-EKB 569);EKB-569; WAY-EKB 569; EKB569; EKB 569;(2E)-N-{4-[(3-chloro-4-fluorophenyl)aMino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(diMethylaMino)but-2-enaMide;(E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
CAS:	257933-82-7
MF:	C24H23ClFN5O2
MW:	467.92
EINECS:	803-625-4
Product Categories:	Inhibitors;Intermediates & Fine Chemicals;All Inhibitors;pyridine;Pharmaceuticals;Tyrosine Kinase Inhibitors;API;Aromatics;Heterocycles;Isotope Labelled Compounds
Mol File:	257933-82-7.mol

PELITINIB Chemical Properties

Melting point	173-178°C
Boiling point	655.5±55.0 °C(Predicted)
density	1.34
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO: soluble5mg/mL, clear (warmed)
form	powder
pka	12.23±0.43(Predicted)
color	white to beige

Safety Information

Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
HazardClass	6.1
PackingGroup	III

MSDS Information

PELITINIB Usage And Synthesis

Description	Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC₅₀ = 39 nM). It inhibits HER2 with a much weaker potency (IC₅₀ = 1.2 μM). By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC₅₀s = ~2 μM).
Chemical Properties	Off-White Solid
Uses	Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
Uses	An EGFR inhibitor
Uses	Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.
references	[1] torrance cj, jackson pe, montgomery e, kinzler kw, vogelstein b, wissner a, nunes m, frost p, discafani cm. combinatorial chemoprevention of intestinal neoplasia. nat med. 2000 sep;6(9):1024-8.[2] nunes m, shi c, greenberger lm. phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase b, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, ekb-569, in tumor cells and normal human keratinocytes. mol cancer ther. 2004 jan;3(1):21-7.

PELITINIB Preparation Products And Raw materials

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