Other grades of this product :
| 1-BENZHYDRYLPIPERAZINE Basic information |
| 1-BENZHYDRYLPIPERAZINE Chemical Properties |
| Melting point | 90-93 °C | | Boiling point | 185°C/2mmHg(lit.) | | density | 1.0546 (rough estimate) | | vapor pressure | 0.001Pa at 20℃ | | refractive index | 1.5794 (estimate) | | Fp | 115 °C | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Methanol (Slightly) | | pka | 9.05±0.10(Predicted) | | form | Crystalline Powder | | color | White to light yellow | | Water Solubility | 0.45 g/L (20 ºC) | | Sensitive | Air Sensitive | | BRN | 222773 | | LogP | 0.6 at 20℃ | | CAS DataBase Reference | 841-77-0(CAS DataBase Reference) | | NIST Chemistry Reference | Benzhydryl piperazine(841-77-0) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22 | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | TL6465000 | | F | 34 | | HazardClass | IRRITANT | | HS Code | 29339900 |
| 1-BENZHYDRYLPIPERAZINE Usage And Synthesis |
| Chemical Properties | white to light yellow crystalline powder | | Uses | 1-Benzhydrylpiperazine is an intermediate used in drug synthesis
| | Uses | Cinnarizine (C465300) impurity. | | Uses | 1-(Diphenylmethyl)piperazine [N-(Diphenylmethyl)piperazine] may be used for the synthesis of 2-nitro-3,4,4-trichloro-1-(propylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene and 2-nitro-3,4,4-trichloro-1-(octadecylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene. | | Synthesis Reference(s) | Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006 | | General Description | 1-(Diphenylmethyl)piperazine is an intermediate during drug synthesis. It has been reported to be formed during the oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] in rat liver microsomes. It reacts with quinone in acetonitrile, followed by oxidation with an alkaline potassium ferricyanide, to afford 4-amino-3,6-di(tert-butyl)-o-benzoquinones. | | Flammability and Explosibility | Notclassified |
| 1-BENZHYDRYLPIPERAZINE Preparation Products And Raw materials |
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