Potassium bis(trimethylsilyl)amide

CAS No.：40949-94-8

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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Potassium bis(trimethylsilyl)amide Basic information

Product Name:	Potassium bis(trimethylsilyl)amide
Synonyms:	1,1,1,3,3,3-HEXAMETHYLDISILAZANE POTASSIUM SALT;KHMDS;HEXAMETHYLDISILAZANE POTASSIUM SALT;HEXAMETHYLDISLAZANE POTASSIUM SALT;POTASSIUM BIS(TRIMETHYLSILYL)AMIDE;POTASSIUMHEXAMETHYLDISILAZANE;POTASSIUM HEXAMETHYLDISILAZIDE;POTASSIUM HEXAMETHYLDISLAZANE
CAS:	40949-94-8
MF:	C6H18KNSi2
MW:	199.48
EINECS:	424-100-2
Product Categories:	25mL Sure/Seal Reagents;Aliphatics;Chemical Synthesis;Organic Bases;Organometallic Reagents;Synthetic Reagents;Analytical Chemistry;GC Derivatizing Reagents;Si (Classes of Silicon Compounds);Classes of Metal Compounds;K (Potassium) Compounds (excluding simple potassium salts);Silicon Compounds (for Synthesis);Synthetic Organic Chemistry;Typical Metal Compounds;Silazanes;Silylation (GC Derivatizing Reagents);Si-N Compounds;Trimethylsilylation (GC Derivatizing Reagents)
Mol File:	40949-94-8.mol

Potassium bis(trimethylsilyl)amide Chemical Properties

Melting point	194-195°C
Boiling point	111 °C
density	0.877 g/mL at 25 °C
vapor density	3.2 (vs air)
vapor pressure	54 mm Hg ( 25 °C)
refractive index	1.4920
Fp	45 °F
storage temp.	Refrigerator
solubility	Miscible with terahydrofuran, ether, benzene and toluene.
form	Liquid
Specific Gravity	0.877
color	clear to slightly hazy yellow
Water Solubility	Reacts with water.
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
Sensitive	Moisture Sensitive
BRN	4006754
CAS DataBase Reference	40949-94-8(CAS DataBase Reference)
EPA Substance Registry System	Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, potassium salt (1:1) (40949-94-8)

Safety Information

Hazard Codes	C,F,Xn
Risk Statements	14-34-67-65-63-48/20-11-40-36/37/38-19-37
Safety Statements	26-36/37/39-45-62-43-46-16-36/37
RIDADR	UN 3263 8/PG 3
WGK Germany	3
F	1-3-10
TSCA	No
HazardClass	3
PackingGroup	II
HS Code	29319090

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

Potassium bis(trimethylsilyl)amide Usage And Synthesis

Chemical Properties	Colorless to amber solution
Uses	Potassium bis(trimethylsilyl)amide is a strong base used in the alkylation carbonyl compounds.1
Uses	Potassium Hexamethyldisilazide is widely used as a Sterically Hindered Base for Enolate Generation in Selective Formation of Linear Conjugated Dienolates and Alkyl (Z)-3-Alkenoates.
Uses	Potassium Bis(trimethylsilyl)amide (1M in THF) is used in the preparation of 5-azacytidine, an antineoplastic drug. Also applied in the preparation of β3-AR agonists used in anti-stress formulations. It is also used as a reagent in the preparation of lanthanide complexes employed in selective cyclization reactions.
Preparation	Potassium Hexamethyldisilazide is prepared and isolated by the procedure of Wannagat and Niederpruem. A more convenient in situ generation from potassium hydride and hexamethyldisilane is described by Brown.
General Description	This product, 1.0 M in 2-methyltetrahydrofuran aligns with "Safer Solvents and Auxiliaries", "Use of Renewable Feedstocks" and "Inherently Safer Chemistry for Accident Prevention".

Potassium bis(trimethylsilyl)amide Preparation Products And Raw materials

Preparation Products

CYCLOHEXANE-1 4-DICARBONITRILE 98% MIXT&

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