BOC-Glycine

CAS No.：4530-20-5

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BOC-Glycine Basic information

Product Name:	BOC-Glycine
Synonyms:	BOC-Glycine, 99+%;Boc-glycin;N-tert-Boc-glycine-OH;BOC-GLYCINE(N-TERT-BUTOXYCARBONYLGLYCINE);n-[(1,1-dimethylethoxy)carbonyl]-glycin;glycine(sterile);N-ALPHA-T-BUTYLOXYCARBONYL-GLYCINE;BOC-L-GLY-OH
CAS:	4530-20-5
MF:	C7H13NO4
MW:	175.18
EINECS:	224-864-5
Product Categories:	Intermediates & Fine Chemicals;Glycine [Gly, G];Amino Acids;Boc-Amino Acids and Derivative;Amino Acids 13C, 2H, 15N;Absolute Configuration Determination (Exciton Chirality CD Method);Amino Acids (N-Protected);Analytical Chemistry;Biochemistry;Boc-Amino Acids;Enantiomer Excess & Absolute Configuration Determination;Exciton Chirality CD Methodfor (for Monofunctional Compounds);Boc-Amino acid series;Amino Acids & Derivatives;Protected Amino Acids;AMINOACIDS DERIVATIVES;Amino Acid Derivatives;PROTECTED AMINO ACID & PEPTIDES;Pharmaceuticals
Mol File:	4530-20-5.mol

BOC-Glycine Chemical Properties

Melting point	86-89 °C(lit.)
Boiling point	306.47°C (rough estimate)
density	1.2843 (rough estimate)
refractive index	1.4353 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Powder
pka	4.00±0.10(Predicted)
color	White to off-white
Water Solubility	soluble
BRN	1101514
CAS DataBase Reference	4530-20-5(CAS DataBase Reference)
EPA Substance Registry System	Glycine, N-[(1,1-dimethylethoxy)carbonyl]- (4530-20-5)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-41-36/37/38-20/21/22
Safety Statements	26-36/37/39-39-36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
TSCA	Yes
HS Code	29241990

MSDS Information

Provider	Language
Boc-Gly-OH	English
SigmaAldrich	English
ACROS	English
ALFA	English

BOC-Glycine Usage And Synthesis

Chemical Properties	White To Off-White Powder
Uses	BOC-Glycine is used in the composition of drugs containing Ketoprofen, and Sodium hyaluronate as antiinflammatory agents.
Uses	Boc-Gly-OH can be used: For the esterification reaction to synthesize N-Boc amino acid esters for peptide chemistry. For the synthesis of tripeptide H-Gly-Pro-Glu-OH, analogs of neuroprotective drugs. As a promoter for the allylation of hydrazones and isatin.
Synthesis Reference(s)	Tetrahedron Letters, 16, p. 4393, 1975 DOI: 10.1016/S0040-4039(00)91133-X

BOC-Glycine Preparation Products And Raw materials

Raw materials	Ethyl acetate-->1,4-Dioxane-->Glycine
Preparation Products	BOC-D-Phenylalanine-->TERT-BUTYL 3-(ETHOXYCARBONYL)-2-OXOPROPYLCARBAMATE-->N-Boc-N-methyl glycine methyl ester-->2,5-OXAZOLIDINEDIONE-->N-(tert-Butoxycarbonyl)-2-aminoacetonitrile-->(1H-BENZO[D]IMIDAZOL-2-YL)METHANAMINE-->BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE-->N-desalkylflurazepam

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