2-Amino-6-fluorobenzonitrile

CAS No.：77326-36-4

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Amino-6-fluorobenzonitrile Basic information

Product Name:	2-Amino-6-fluorobenzonitrile
Synonyms:	2-FLUORO-6-AMINOBENZONITRILE;2-AMINO-6-FLUOROBENZONITRILE;6-FLUOROANTHRANILONITRILE;6-AMINO-2-FLUOROBENZONITRILE;2-Amino-6-fluorobenzonitrile, 97+% (6-Fluoroanthranilonitrile);Benzonitrile, 2-amino-6-fluoro- (9CI);2-Amino-6-fluorobenzonitrile 98%;2-Amino-6-fluorobenzonitrile98%
CAS:	77326-36-4
MF:	C7H5FN2
MW:	136.13
EINECS:
Product Categories:	Aromatic Nitriles;Benzene series;NITRILE;Amines;Aromatics;Miscellaneous Reagents
Mol File:	77326-36-4.mol

2-Amino-6-fluorobenzonitrile Chemical Properties

Melting point	125-128 °C (lit.)
Boiling point	275.8±25.0 °C(Predicted)
density	1.25±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform
form	Solid
pka	0.80±0.10(Predicted)
color	Pale Yellow
BRN	3588945
CAS DataBase Reference	77326-36-4(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,T,Xn
Risk Statements	36-36/37/38-20/21/22
Safety Statements	26-36-36/37/39-22
RIDADR	3439
WGK Germany	2
Hazard Note	Irritant
HazardClass	6.1
PackingGroup	III
HS Code	29269090

MSDS Information

Provider	Language
2-Amino-6-fluorobenzonitrile	English
SigmaAldrich	English
ALFA	English

2-Amino-6-fluorobenzonitrile Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	2-Amino-6-fluorobenzonitrile, a medicinal chemistry intermediate, has been employed for the preparation of tacrine-related compounds. It may be used for the synthesis of antifolate and antibacterial quinazoline derivatives. It may be used for the synthesis bis(4-oxoquinazolin-2-yl)pyridine and fluoro-containing quinazolin-4(1H)-ones. It may be employed for the synthesis of the following novel huprines: 12-amino-3-chloro-6,7,10,11-tetrahydro-9-isopropyl-7,11-methanocycloocta[b]quinoline hydrochloride 9-allyl-12-amino-3-chloro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline hydrochloride 12-amino-1-fluoro-6,7,10,11-tetrahydro-9-isopropyl-7,11-methanocycloocta[b]quinoline hydrochloride 9-allyl-12-amino-1-fluoro-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline hydrochloride
General Description	2-Amino-6-fluorobenzonitrile can be prepared by treatment of 2,6- difluorobenzonitrile with ammonia, which involves displacement of one of the activated fluorine atoms.

2-Amino-6-fluorobenzonitrile Preparation Products And Raw materials

Preparation Products

2-AMINO-6-BROMOBENZONITRILE

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