Other grades of this product :
| TRICHOSTATIN A Basic information |
| Product Name: | TRICHOSTATIN A | | Synonyms: | 7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide;7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID;Trichostatin A from Streptomyces platensis;[r-(e,e)]-7-[4-(dimethylamino)phenyl]-n-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide;7-(4-DIMETHYLAMINOPHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-HEPTA-2,4-DIENAMIDE;TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide | | CAS: | 58880-19-6 | | MF: | C17H22N2O3 | | MW: | 302.37 | | EINECS: | 611-758-2 | | Product Categories: | Inhibitors;antibiotic;Anti Cancer Research;Inhibitor;API | | Mol File: | 58880-19-6.mol |
| TRICHOSTATIN A Chemical Properties |
| Melting point | 140-143℃ | | alpha | D20.5 +62.8° ±1.1° (c = 1.007 in ethanol) | | density | 1.139 | | refractive index | 136 ° (C=0.3, MeOH) | | storage temp. | -20°C | | solubility | ethanol: 1 mg/mL | | form | Off-white lyophilized solid | | pka | 8.93±0.23(Predicted) | | color | Tan | | Merck | 14,9649 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | InChIKey | ZWGICMNKJBUOHG-RCXLNATQSA-N |
| TRICHOSTATIN A Usage And Synthesis |
| Description | Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo. | | Chemical Properties | Solid | | Uses | Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells. | | Uses | Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity | | Uses | Trichostatin A, ready-made solution has been used:- as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing
- to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)
- to treat cells for the HDAC inhibition experiments
| | General Description | Trichostatin A is a compound of primary hydroxamic acid. | | Biological Activity | Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. | | Biochem/physiol Actions | Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA. | | References | 1) Yoshida et al. (1990), Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A ; J. Biol. Chem., 265 17174
2) Futamura et al. (1995), Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells; Oncogene, 10 1119
3) Durcova-Hills et al. (2008), Reprogramming Primordial Germ Cells into Pluripotent Stem Cells; PLoS-One, 3 e3531 |
| TRICHOSTATIN A Preparation Products And Raw materials |
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