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| BRD73954 Basic information |
| Product Name: | BRD73954 | | Synonyms: | N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide;BRD73954;N1-hydroxy-N3-phenethylisophthalamide;N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954;BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide;BRD-73954;BRD 73954;CS-1777;1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)- | | CAS: | 1440209-96-0 | | MF: | C16H16N2O3 | | MW: | 284.31 | | EINECS: | | Product Categories: | Inhibitors | | Mol File: | 1440209-96-0.mol |
| BRD73954 Chemical Properties |
| Melting point | 172-175oC | | density | 1.245±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 8.56±0.10(Predicted) | | color | Off-White |
| BRD73954 Usage And Synthesis |
| Description | BRD73954 is a dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 (IC50s = 36 and 120 nM, respectively). It is selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC50s = 12, 9, 23, >33, >33, 13, and >33 μM, respectively). BRD73954 (10 μM) increases acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, -2, and -3, in HeLa cells. | | Uses | BRD73954 is a small molecule inhibitor which has the ability to inhibit HDAC6 and HDAC8. Affects cell adhesion and mobility in cells. | | references | [1]. olson de, wagner ff, kaya t, et al. discovery of the first histone deacetylase 6/8 dual inhibitors. j med chem, 2013, 56(11): 4816-4820. |
| BRD73954 Preparation Products And Raw materials |
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