Diphenylphosphinyl chloride

CAS No.：1499-21-4

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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Diphenylphosphinyl chloride Basic information

Product Name:	Diphenylphosphinyl chloride
Synonyms:	Diphenyl phosphilic chloride;Diphenylphoshinic;DIPHENYLPHOSHINIC CHLORIDE;Diphenylchlorophosphine oxide;Diphenylphosphinyl chloride,98%;(Chloro-phenylphosphoryl)benzene;Diphenylphosphinic acid chloride;Diphenylphosphinicchloride,98%
CAS:	1499-21-4
MF:	C12H10ClOP
MW:	236.63
EINECS:	216-107-2
Product Categories:	Biochemistry;Coupling Reactions (Peptide Synthesis);Peptide Synthesis;Protection & Derivatization Reagents (for Synthesis);Reagents for Oligosaccharide Synthesis;Synthetic Organic Chemistry;Pharmaceutical Intermediates;Phosphorus compounds;organophosphorus compound;Morpholines/Thiomorpholines
Mol File:	1499-21-4.mol

Diphenylphosphinyl chloride Chemical Properties

Melting point	20°C
Boiling point	222 °C/16 mmHg (lit.)
density	1.24 g/mL at 25 °C (lit.)
refractive index	n20/D 1.609(lit.)
Fp	79 °F
storage temp.	2-8°C
form	Liquid
color	Clear colorless to yellow
Specific Gravity	1.24
Water Solubility	decomposes
Sensitive	Moisture Sensitive
BRN	975191
CAS DataBase Reference	1499-21-4(CAS DataBase Reference)
NIST Chemistry Reference	Diphenylphosphinic chloride(1499-21-4)

Safety Information

Hazard Codes	C,F
Risk Statements	10-34
Safety Statements	16-26-36/37/39-45
RIDADR	UN 2920 8/PG 2
WGK Germany	3
F	10-21
Hazard Note	Flammable/Corrosive
HazardClass	8
PackingGroup	II
HS Code	29310095

MSDS Information

Provider	Language
Chlorodiphenylphosphine oxide	English
SigmaAldrich	English
ACROS	English
ALFA	English

Diphenylphosphinyl chloride Usage And Synthesis

Chemical Properties	clear colorless to yellow liquid
Uses	Diphenylphosphinic chloride (Ph₂POCl) is widely used as a precursor to synthesize various chiral phosphine bidentate ligands for asymmetric synthesis, in addition to several peptide coupling agents.

Diphenylphosphinyl chloride Preparation Products And Raw materials

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