3-COUMARANONE

CAS No.：7169-34-8

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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3-COUMARANONE Basic information

Product Name:	3-COUMARANONE
Synonyms:	3-Oxocoumaran;3-Coumaranonebenzofuran-3(2H)-one;Benzo[b]furan-3(2H)-one;1-Benzofuran-3(2H)-one;1-Benzofuran-3(2H)-one, Coumaran-3-one;2,3-dihydro-1-benzofuran-2-one;1-Benzofuran-3(2H)-one, Coumaran-3-one, 2,3-Dihydro-3-oxo-1-benzofuran;Benzofuran-3(2H)-one >=98.0% (HPLC)
CAS:	7169-34-8
MF:	C8H6O2
MW:	134.13
EINECS:	640-279-1
Product Categories:	Benzofurans;Building Blocks;pharmacetical;Fused Ring Systems;Chemical Synthesis;Heterocyclic Building Blocks;Furan&Benzofuran
Mol File:	7169-34-8.mol

3-COUMARANONE Chemical Properties

Melting point	101-103 °C
Boiling point	207.23°C (rough estimate)
density	1.1603 (rough estimate)
refractive index	1.4800 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly), DMSO (Slightly)
form	Solid
color	Yellow to Dark Yellow
Water Solubility	Slightly miscible with water.
Sensitive	Light Sensitive
BRN	115296
CAS DataBase Reference	7169-34-8(CAS DataBase Reference)
NIST Chemistry Reference	3(2H)-benzofuranone(7169-34-8)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22
Safety Statements	22-24/25-36/37/39-26-36
WGK Germany	3
F	4.5-9
Hazard Note	Irritant
HS Code	29329990

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

3-COUMARANONE Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	3-Coumaranone is used in the aurones, [2-benzylidenebenzofuran-3(2H)-ones] by reacting with appropriate aldehyde. It is involved in the condensation reaction with aldehydes in the presence of morpholine acetate to prepare substituted 2-(arylidene)benzofuran-3(ZH)-ones. In Horner-Wadsworth-Emmons reaction, it reacts with diethyl? cyanomethyl?phosphonate to give 3-(cyanomethyl)benzofurans, which is an intermediate in the synthesis of antihyperglycemic agents.
General Description	Benzofuran-3(2H)-one undergoes condensation with aldehydes in the presence of morpholine acetate to yield substituted 2-(arylidene)benzofuran-3(ZH)-ones. It undergoes acid- or base-catalyzed condensation with an appropriate aldehyde to yield aurones [2-benzylidenebenzofuran-3(2H)-ones].

3-COUMARANONE Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Hydrochloric acid-->Methanol-->Tetrahydrofuran-->Acetic acid-->N,N-Dimethylformamide-->Potassium carbonate-->Chloroform-->Government regulation-->Magnesium sulfate-->Acetic anhydride-->Acetone-->Sodium acetate-->Ethyl bromoacetate-->2'-Hydroxyacetophenone-->Methyl salicylate
Preparation Products	Benzofuran-2-boronic acid

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