QUININE SULFATE

QUININE SULFATE
  • CAS No.:804-63-7
Other grades of this product :
QUININE SULFATE Basic information
Product Name:QUININE SULFATE
Synonyms:Quinine sulfate(2:1);6’-methoxy-cinchonan-9-o(8alpha,9theta)-cinchonan-9-osulfate(2:1)(salt);Cinchonan-9-ol,6’-methoxy-,(8.alpha.,9R)-,sulfate(2:1)(salt);legatrin;quininehydrogensulfate;QUININE HEMISULFATE;QUININE BISULFATE;QUININE SULFATE
CAS:804-63-7
MF:C40H50N4O8S
MW:746.91
EINECS:212-359-2
Product Categories:Organics
Mol File:804-63-7.mol
QUININE SULFATE Chemical Properties
Melting point 235.2°C
density 1.0807 (rough estimate)
refractive index 1.6000 (estimate)
CAS DataBase Reference804-63-7(CAS DataBase Reference)
EPA Substance Registry SystemQuinine sulfate (2:1) (804-63-7)
Safety Information
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR 1544
HazardClass 6.1(b)
PackingGroup III
HS Code 29339900
MSDS Information
QUININE SULFATE Usage And Synthesis
Chemical PropertiesWhite powder
Usesntimalarial.
UsesQuinine, an extremely bitter substance, has been used by millions of malaria sufferers. In recent times, it has been employed successfully to treat chloroquine-resistant strains of P. falciparum but it frequently fails to provide a complete cure of the infection.
DefinitionChEBI: A organic sulfate salt obtained from guanethidine and sulfuric acid in a 2:1 ratio.
Brand nameCoco-Quinine (Lilly).
World Health Organization (WHO)Quinine is an important drug in the treatment of multi- drugresistant forms of malaria. Its use in nocturnal leg muscle cramps, a benign and self-limiting condition, is connected with unjustified risks. Quinine is listed in the WHO Model List of Essential Drugs for treatment of malaria.
Safety ProfileHuman poison by ingestion. Human systemic effects by ingestion: acuity changes, blood agranulocytosis, fibrous hepatitis, flaccid paralysis without anesthesia, motor activity changes, mydriasis (pupillary dilation), nausea or vomiting, tinnitus, visual field changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NO,. See also QUININE.
Purification MethodsCrystallise it from water and dry it at 110o. [Beilstein 23 H 522, 23 I 168, 23 II 420, 23 III/IV 3269, 23 V 396.]
QUININE SULFATE Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Cinchonidine-->Quinine-->Cinchonine-->Cinchona ledgeriana bark-->Quinidine
Preparation Products(S)-(-)-1,2,3,4-Tetrahedro-naphthoic acid

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