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| Diethyl bromodifluoromethanephosphonate Basic information |
| Diethyl bromodifluoromethanephosphonate Chemical Properties |
| Boiling point | 40-41 °C/0.05 mmHg (lit.) | | density | 1.503 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.417(lit.) | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform, Ethyl Acetate | | form | liquid | | Specific Gravity | 1.503 | | color | colorless | | Water Solubility | Not miscible or difficult to mix in water. | | BRN | 1944045 | | CAS DataBase Reference | 65094-22-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 21/22-36/38-38-36 | | Safety Statements | 26-36/37/39-60-37-23 | | RIDADR | 3278 | | WGK Germany | 3 | | Hazard Note | Irritant | | TSCA | No | | HazardClass | IRRITANT, IRRITANT-HARMFUL | | PackingGroup | III | | HS Code | 29319090 |
| Diethyl bromodifluoromethanephosphonate Usage And Synthesis |
| Uses | Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis. | | Uses | Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 49, p. 3437, 1984 DOI: 10.1021/jo00192a056 |
| Diethyl bromodifluoromethanephosphonate Preparation Products And Raw materials |
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