Product

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

CAS No.：53554-29-3

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1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Basic information

Product Name:	1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER
Synonyms:	1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-;5-PyriMidinecarboxylicacid, 1,6-dihydro-2-(Methylthio)-6-oxo-, ethyl ester;Ethyl 2-Methylsulfanyl-6-oxo-1h-pyriMidine-5-carboxylate;Ethyl 2-(Methylthio)-6-oxo-1,6-dihydropyriMidine-5-carboxylate;1,4-dihydro-2-Methyl-4-oxo-5-Mercapto-pyriMidine-carboxylic acid ethyl ester;Ethyl 2-(methylsulfanyl)-4-oxo-1,4-dihydropyrimidine-5-carboxylate;1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-;1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINECARBOXYLIC ACID ETHYL ESTER >98%
CAS:	53554-29-3
MF:	C8H10N2O3S
MW:	214.24
EINECS:
Product Categories:	pyrimidine
Mol File:	53554-29-3.mol

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Chemical Properties

Melting point	136-144°C
density	1.37±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	6.48±0.50(Predicted)
CAS DataBase Reference	53554-29-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
HazardClass	IRRITANT
HS Code	2933599590

MSDS Information

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Usage And Synthesis

Uses

1,4-Dihydro-2-methylmercapto-4-oxo-5-pyrimidinecarboxylic acid ethyl ester can be used as several synthetic intermediates and pharmaceutical intermediates, mainly used in laboratory research and development process and pharmaceutical and chemical production process.

Synthesis

Methylthiourea sulfate (75.2g, 0.4mol) was added to 16% NaOH (250mL, 1.18mol) solution and stirred for 30min, then diethyl ethoxymethylenemalonate (103.4g, 0.48 mol) was dissolved in 160 mL of ethanol and slowly dropped into the reaction solution. After the dropwise addition was completed, the reaction was carried out at room temperature for 10 h.When a large amount of white solid was precipitated, carry out suction filtration, wash with water, and vacuum dry to obtain a white solid (84.7g, 99.7%); ESE-MS (m/z): 249[M+H]+, 236.9[M+Na]+ , after verification, the product is 1,4-dihydro-2-methylmercapto-4-oxo-5-pyrimidinecarboxylic acid ethyl ester.

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials	Ethanol-->Sodium-->Phosphorus oxychloride-->Potassium hydroxide-->Acetic anhydride-->Benzene-->Triethyl orthoformate-->Diethyl malonate-->2-Methyl-2-thiopseudourea sulfate-->Diethyl ethoxymethylenemalonate
Preparation Products	5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)- 1-pyrrolidinyl]-

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