Dibucaine hydrochloride

Dibucaine hydrochloride
  • CAS No.:61-12-1

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
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Dibucaine hydrochloride Basic information
Product Name:Dibucaine hydrochloride
Synonyms:2-butoxy-n-(2-(diethylamino)ethyl)-4-quinolinecarboxamidmonohydrochlorid;Dibucaine (Cinchocaine) HCl;2-butoxy-n-(2-(diethylamino)ethyl)-cinchoninamidmonohydrochloride;2-butoxy-n-(2-diethylaminoethyl)cinchoninicacidamidehydrochloride;2-n-butoxy-n-(2-diethylaminoethyl)cinchoninamidehydrochloride;4-Quinolinecarboxamide,2-butoxy-N-[2-(diethylamino)ethyl]-,monohydrochloride;benzolin(localanesthetic);butoxycinchoninicaciddiethylethylenediamidehydrochloride
CAS:61-12-1
MF:C20H30ClN3O2
MW:379.92
EINECS:200-498-1
Product Categories:API;NUPERCAINAL;Amines;Heterocycles;Intermediates & Fine Chemicals;Other APIs;Pharmaceuticals;API
Mol File:61-12-1.mol
Dibucaine hydrochloride Chemical Properties
Melting point 99-101 °C(lit.)
density 1.1338 (rough estimate)
refractive index 1.5400 (estimate)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Hygroscopic crystals
PHpH(20g/l,25℃) : 5.0~6.0
Water Solubility Freely soluble in water, alcohol, acetone, or chloroform
Merck 13,3057
Stability:Stable. Incompatible with strong oxidizing agents. Protect from moisture.
CAS DataBase Reference61-12-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22-41
Safety Statements 26-39
WGK Germany 3
RTECS GD3325000
HS Code 2933492250
Toxicityeye-rbt 2% SEV ARZNAD 8,181,58
Dibucaine hydrochloride Usage And Synthesis
Chemical Propertieswhite powder
UsesAnesthetic (local).
UsesCinchocaine is used as an anaesthetic agent for spinal anaesthesia; a component in rectal medications used in inflammation of the anus and for the symptomatic treatment of hemorrhoids and fissures in the anus; local anesthetic agent.
UsesDibucaine HCl is an amide-like quinoline derivative and is one of the most potent and longest acting of the commonly used local anesthetics.
DefinitionChEBI: The monohydrochloride salt of cinchocaine. It is used in creams, ointments and suppositories for temporary relief of pain and itching associated with skin and anorectal conditions.
Brand nameNupercaine (Novartis).
Contact allergensDibucaine hydrochloride is an amide group local anesthetic that can induce allergic contact dermatitis.
Safety ProfilePoison by ingestion,subcutaneous, intravenous, intraspinal, parenteral, andintraperitoneal routes. Mutation data reported. A severeeye irritant. A local anesthetic. When heated todecomposition it emits very toxic fumes of HCl and NOx
Dibucaine hydrochloride Preparation Products And Raw materials
Raw materialsDi-n-butyl ether-->3-METHOXYPROPIONIC ACID-->2-Quinolinol-->Cinchocaine

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