Other grades of this product :
| Anticholinesterase Basic information |
| Product Name: | Anticholinesterase | | Synonyms: | Esterase, acetyl choline;TRUE CHOLINESTERASE;TRUE CHOLINESTERASE HUMAN;TRUE CHOLINESTERASE TYPE VI-S;TRUE CHOLINESTERASE TYPE V-S;TRUE CHOLINESTERASE TYPE XII-S;ACETYLCHOLINESTERASE TYPE III ELECTRIC;ACETYLCHOLINE ESTERASE F. ELECTROPHORUS ELECT., ~850 U/MG | | CAS: | 9000-81-1 | | MF: | NULL | | MW: | 0 | | EINECS: | 232-559-3 | | Product Categories: | | Mol File: | Mol File |
| Anticholinesterase Chemical Properties |
| storage temp. | -20°C | | solubility | H2O: 1 mg/mL | | form | powder | | color | slightly yellow |
| Hazard Codes | B | | WGK Germany | 3 | | F | 10-21 | | Toxicity | The inhibition of AChE by these anticholinesterases leads to an accumulation of
endogenous ACh, and thus results in hyperactivation of cholinergic
receptors. Signs of acute poisoning can include irritability,
tremors, convulsions, and predominately parasympathetic
effects, with death usually the result of respiratory failure.
Since AChE is contained in erythrocytes, the assay of erythrocyte
AChE activity can be used as a diagnostic tool to assess
exposure to organophosphorus anticholinesterases. |
| Anticholinesterase Usage And Synthesis |
| Uses | Pesticides. | | Uses | Acetylcholinesterase (AChE) from Sigma has been used in the structure-activity study of phosphoramido acid esters as inhibitors of AChE. | | Uses | Acetylcholinesterase from Electrophorus electricus (electric eel) has been used:- in acetylcholinesterase activity assay
- to study its effects on Xenopus embryonic hippocampal cells
- to study the effect of acetylcholine inhibitors on development and plasticity
| | Definition | Any substance that inhibits or inactivates acetylcholinesterase, thereby preventing the hydrolysis of acetylcholine. Their action leads to an accumulation of endogenous acetylcholine with a resultant hyperactivity of cholinergic neurons, which can prove lethal. | | General Description | Predominantly exists as a tetrameric glycoprotein composed of disulfide-linked homodimers with a monomer MW of ~80 kDa. | | Hazard | Tremors; convulsions; respiratory failure; death. | | Biochem/physiol Actions | Acetylcholinesterase (AChE) is regarded as a biomarker in neurotoxicity. It is a modulator of nitric oxide signal transduction pathway and marker of membrane integrity and aging. The levels of erythrocyte (RBC) AChE are affected on pesticide exposure and in hemolytic anemia. RBC AChE is a marker in Hirschsprung′s disease and inflammation. |
| Anticholinesterase Preparation Products And Raw materials |
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