Other grades of this product :
| EC 1.1.1.42 Basic information |
| Product Name: | EC 1.1.1.42 | | Synonyms: | THREO-DS-ISOCITRATE: NADP+ OXIDOREDUCTASE;THREO-DS-ISOCITRATE: NADP(+) OXIDOREDUCTASE[DECARBOXYLATING];THREO-DS-ISOCITRATE: NADP(+) OXIDOREDUCTASE[DECARBOXYLATING] TYPE I;THREO-DS-ISOCITRATE: NADP(+) OXIDOREDUCTASE[DECARBOXYLATING] TYPE IV;isocitrate dehydrogenase from porcine heart;ICDH;ISOCITRIC DEHYDROGENASE (NADP);ISOCITRIC DEHYDROGENASE (NADP) TYPE I | | CAS: | 9028-48-2 | | MF: | NULL | | MW: | 0 | | EINECS: | 232-835-3 | | Product Categories: | enzyme | | Mol File: | Mol File |
| EC 1.1.1.42 Chemical Properties |
| storage temp. | 2-8°C | | form | solution (clear) | | color | yellow-brown |
| WGK Germany | 3 | | F | 10 | | HS Code | 3507909090 |
| EC 1.1.1.42 Usage And Synthesis |
| Uses | Human Isocitrate Dehydrogenase (IDH1) is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. It may be useful as a biomarker for diagnosis and prognosis prediction of non-small cell lung cancer . | | General Description | Isocitrate dehydrogenase 1 (IDH1) gene is located on human chromosome 2q33. IDH1 is present in the cytoplasm and peroxisomes. It is expressed at high levels in the mammalian liver. IDH1 consists of a C-terminal tripeptide peroxisome, that targets the signal one sequence. | | Biochem/physiol Actions | Isocitrate dehydrogenase 1 (IDH1) help in the oxidative carboxylation of isocitrate to α-ketoglutarate, that results in the formation of reduced nicotinamide adenine dinucleotide phosphate (NADPH). It participates in lipid metabolism and glucose sensing. Suppressing IDH1 in pancreatic islets affects the insulin secretion, induced by glucose and leads to increase in lactate production. |
| EC 1.1.1.42 Preparation Products And Raw materials |
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