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| Methyl pyruvate Basic information |
| Methyl pyruvate Chemical Properties |
| Melting point | -22 °C | | Boiling point | 134-137 °C (lit.) | | density | 1.13 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.404(lit.) | | Fp | 103 °F | | storage temp. | 2-8°C | | solubility | ethanol: soluble1.1g/10 mL, clear, colorless to almost colorless | | form | liquid | | color | Yellow | | Water Solubility | Soluble in chloroform, methanol, ether, alcohol. Slightly soluble in water. | | Merck | 14,8021 | | BRN | 1361953 | | CAS DataBase Reference | 600-22-6(CAS DataBase Reference) | | NIST Chemistry Reference | Propanoic acid, 2-oxo-, methyl ester(600-22-6) |
| Hazard Codes | Xi,F | | Risk Statements | 10 | | Safety Statements | 23-24/25-16 | | RIDADR | UN 3272 3/PG 3 | | WGK Germany | 3 | | F | 10-21 | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29183000 |
| Methyl pyruvate Usage And Synthesis |
| Chemical Properties | Methyl pyruvate is a clear, light yellow, and flammable
liquid. | | Uses | Methyl Pyruvate acts as a potent secretagogue used in the study of stimulus-secretion coupling. Also used in the preparation of quinoxalines as dual phoosphodiesterase 2/10 (PDE2/10) inhibitors. It increases free calcium ion concentration in the cytosol of pancreatic cells. It is used in the preparation of dimethyl 2,3-dimethylenebutanedioate. | | Uses | Methyl pyruvate may be used to investigate the adsorption and reactivity of methyl pyruvate on Pt{111}. It may be used in the preparation of dimethyl 2,3-dimethylenebutanedioate. | | Definition | ChEBI: Methyl pyruvate is a pyruvate ester resultinf grom the formal condensation of the carboxy group of pyruvic acid with the hydroxy group of methanol. It is a pyruvate ester and a methyl ester. It derives from a pyruvic acid. | | Preparation | Methyl pyruvate has been prepared from the silver salt of pyruvic acid and methyl iodide; from the free acid, by the ethanol-vapor method without a catalyst, by azeotropic removal of the water produced by the reaction of methanol in the presence of p-toluenesulfonic acid (the present method), and by refluxing with methanol in ethylene dichloride using ethanesulfonic acid as a catalyst (73% yield). Pyruvic esters have also been prepared by the catalytic dehydrogenation of lactic acid esters and by the oxidation of ethyl lactate with potassium permanganate. DOI: 10.15227/orgsyn.024.0072 | | General Description | Methyl pyruvate is a pyruvic ester. Surface conditions during Pt/silica EUROPT-1 modified by cinchonidine catalyzed by enantioselective hydrogenation of methyl pyruvate to R-(+)-methyl lactate were investigated. Enantioselective hydrogenation of methyl pyruvate over finely dispersed polyvinylpyrrolidone-stabilized and the corresponding alumina-supported iridium clusters modified with cinchonidine was studied. The molecular orientation and conformation of methyl pyruvate on Ni(111) surface has been investigated in the temperature range 105-220K. Methyl pyruvate is reported to stimulate insulin secretion in vitro and in vivo. |
| Methyl pyruvate Preparation Products And Raw materials |
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