5-Chloro-2-hydroxybenzoic acid

CAS No.：321-14-2

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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5-Chloro-2-hydroxybenzoic acid Basic information

Product Name:	5-Chloro-2-hydroxybenzoic acid
Synonyms:	5-Chlorosalicylic acidKosher & Halal certified99.0-101.0% (Assay on dried basis);5-Chloro-2-hydroxybenzoic acid for synthesis;5 CSA;5-chloro-2-hydroxy-benzoicaci;2-Hydroxy-5-chlorobenzoic acid;JACS-321-14-2;5-chloro-salicylicaci;CHLOROSALICYLIC(5-) ACID
CAS:	321-14-2
MF:	C7H5ClO3
MW:	172.57
EINECS:	206-283-9
Product Categories:	Building Blocks;C7;Carbonyl Compounds;Carboxylic Acids;C-CH;Cell Biology;FINE Chemical & INTERMEDIATES;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Amino Acid Derivatives;Bioactive Small Molecules;Chemical Synthesis;Organic Building Blocks;API Intermediate
Mol File:	321-14-2.mol

5-Chloro-2-hydroxybenzoic acid Chemical Properties

Melting point	171-172 °C(lit.)
Boiling point	244.67°C (rough estimate)
density	1.3766 (rough estimate)
refractive index	1.4580 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	1g/l
form	powder to crystal
pka	pK1:2.63 (25°C)
color	White to Almost white
PH	2.5 (H2O, 20℃)(aqueous suspension)
Water Solubility	1 g/L (20 ºC)
BRN	2046665
CAS DataBase Reference	321-14-2(CAS DataBase Reference)
NIST Chemistry Reference	5-Chlorosalicylic acid(321-14-2)
EPA Substance Registry System	Benzoic acid, 5-chloro-2-hydroxy- (321-14-2)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/38-36/37/38-20/21/22
Safety Statements	26-36-37/39
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	VO2080000
TSCA	Yes
HazardClass	6.1
PackingGroup	III
HS Code	29182990
Toxicity	LD50 oral in rat: 250mg/kg

MSDS Information

Provider	Language
5-Chloro-2-hydroxybenzoic acid	English
SigmaAldrich	English
ACROS	English
ALFA	English

5-Chloro-2-hydroxybenzoic acid Usage And Synthesis

Chemical Properties	OFF-WHITE TO CREAM POWDER
Uses	Moth-proofing, insecticide, intermediate for pharmaceuticals, dyes, pesticides.
Definition	ChEBI: A monohydroxybenzoic acid that is 2-hydroxybenzoic acid in which the hydrogen at position 5 is replaced by chlorine.
Hazard	Toxic by ingestion.

5-Chloro-2-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials	Chlorine-->Salicylic acid-->3,5-Dichlorosalicylic acid-->4-Chloro-1-(methoxymethoxy)benzene-->6-CHLORO-2-METHYL-4H-CHROMEN-4-ONE-->5-CHLORO-2-HYDROXYBENZONITRILE-->3-Chlorosalicylic acid-->2-Bromo-5-chlorobenzoic acid-->2,5-Dichlorobenzoic acid-->4-Chlorophenol-->3-Chlorobenzoic acid
Preparation Products	brotianide-->4-(2-(5-CHOLRO-2-METHOXY BENZAMIDO)ETHYL)BENZENESULFONYL CHLORIDE-->5-CHLORO-2-METHOXYBENZOYL CHLORIDE-->4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide-->5-Chloro-2-methoxybenzoic acid-->Methyl 5-chloro-2-hydroxybenzoate-->Niclosamide-->3-Nitrosalicylic acid-->5-CHLORO-2-HYDROXYBENZYL ALCOHOL-->5-CHLOROSALICYLANILIDE

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