2-HYDROXYCARBAZOLE

CAS No.：86-79-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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2-HYDROXYCARBAZOLE Basic information

Product Name:	2-HYDROXYCARBAZOLE
Synonyms:	AURORA KA-4595;2-HYDROXYCARBAZOLE;carbazol-2-ol;2-Hydroxycarbazol (9H-Carbazol-2-ol),;9H-CARBAZOL-2-OL;2-carbazolol;QS794 2-HYDROXYCARBAZOLE;2-Hydroxy-9H-carbazole
CAS:	86-79-3
MF:	C12H9NO
MW:	183.21
EINECS:	201-699-7
Product Categories:	Intermediates of Dyes and Pigments;Nitrogen cyclic compounds;Building Blocks;Carbazoles;Chemical Synthesis;Heterocyclic Building Blocks
Mol File:	86-79-3.mol

2-HYDROXYCARBAZOLE Chemical Properties

Melting point	270-273 °C (lit.)
Boiling point	316.88°C (rough estimate)
density	1.1261 (rough estimate)
refractive index	1.5880 (estimate)
pka	10.05±0.30(Predicted)
BRN	135859
CAS DataBase Reference	86-79-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,C,T,F
Risk Statements	36/37/38-34
Safety Statements	26-36-37/39-45-36/37/39-27
WGK Germany	2
RTECS	FE6355000
HS Code	2933998090

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

2-HYDROXYCARBAZOLE Usage And Synthesis

Chemical Properties	beige to light brown crystalline powder
Uses	Carbazol has been found possible to distinguish between heparin, heparin derivatives, and other polyuronides of connective tissue. A new modification of the carbazole analysis is useful for determination of d-mannuronic acid in heteropolysaccharides. 2-Hydroxycarbazole was used in the synthesis of isochromene fused carbazol, (4aS,13bR)-2,5,5-trimethyl-3,4,4a,5,8,13b-hexahydroisochromeno[3,4-b]carbazole.
General Description	2-Hydroxycarbazole is a compound structurally related to the Ca²⁺-mobilizing marine toxin, 9-methyl-7-bromoeudistomin. Room temperature electronic absorption and fluorescence spectra of 2-hydroxycarbazole has been studied in concentrated aqueous potassium hydroxide solutions. It undergoes chemoselective N-alkylation using NaH as a base in a THF-DMF solvent system.

2-HYDROXYCARBAZOLE Preparation Products And Raw materials

Raw materials	3-ETHOXY-PHENYL-HYDRAZINE-->[1,1'-Biphenyl]-4-ol, 2'-iodo--->9H-Carbazole-3-carboxaldehyde, 2-hydroxy--->9H-Carbazole,2-ethoxy-(9CI)-->2-HYDROXY-5,6,7,8-TETRAHYDROCARBAZOLE-->2-chloro-9H-carbazole-->Cyclohexanone
Preparation Products	2-METHOXY-9H-CARBAZOLE

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