Nerolidol

CAS No.：40716-66-3

Other grades of this product :

Nerolidol Basic information

Product Name:	Nerolidol
Synonyms:	Teprenone Impurity 19;trans-Nerolidal solution;(6E)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol;1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (E)-;Trans-(E)-Nerolidol;3-Hydroxy-3,7,11-trimethyl-1,6,10-dodecatriene;Nerolidol;(E)-3,7,11-trimethyldodeca-1,6,10-trien-3-ol
CAS:	40716-66-3
MF:	C15H26O
MW:	222.37
EINECS:	255-053-4
Product Categories:
Mol File:	40716-66-3.mol

Nerolidol Chemical Properties

Boiling point	145-146 °C12 mm Hg(lit.)
density	0.876 g/mL at 25 °C(lit.)
refractive index	n20/D 1.479(lit.)
Fp	230 °F
storage temp.	-20°C
form	neat
pka	14.40±0.29(Predicted)
JECFA Number	1646
Merck	13,6501
BRN	5731231
NIST Chemistry Reference	1,6,10-Dodecatrien-3-ol, 3,7,11-trimethyl-, (e)-(40716-66-3)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1
F	10-23
toxicity	Both the acute oral LD₅₀ in rats and the acute dermal LD₅₀ in rabbits exceeded 5 g/kg (Russell. 1973).

MSDS Information

Nerolidol Usage And Synthesis

Description	trans-Nerolidol is a sesquiterpene that has been found in various plants, including C. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties. In a disc assay, trans-nerolidol inhibits the growth of S. aureus, B. subtilis, E. coli, and S. cerevisiae with zones of inhibition measuring 10, 9, 10, and 4 mm, respectively. It reduces viability of CaCo-2 adenocarcinoma cells with an IC₅₀ value of 28.7 mg/L and reduces production of reactive oxygen species (ROS). trans-Nerolidol is insecticidal against A. aegypti larvae with a 24-hour LC₅₀ value of 9 mg/L.
Occurrence	Reported to be found in cabreuva oil, oil of neroli, balsam Peru, ylang ylang and many others (Gildemeister & Hoffman, 1959).
Preparation	By isolation from a suitable essential oil or by chemical synthesis.

Nerolidol Preparation Products And Raw materials

Raw materials	5-Hepten-1-yne, 6-methyl--->Diphosphoric acid, mono[(2Z,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl] ester-->CIS-TRANS-FARNESOL-->GERANYL BROMIDE-->Geranylacetone
Preparation Products	Teprenone Impurity 20-->(E)-BETA-FARNESENE-->(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienal

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