TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA

CAS No.：252881-74-6

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Basic information

Product Name:	TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA
Synonyms:	[(+)-BIOTIN-PEG12-NHS ESTER];H2N-PEG3-CH2CH2-t-butylester;tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate;Amino-PEG3-COOtBu;TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA;H2N-PEG3-tBu;H2N-PEG3-CH2CH2COOtBu;tert-Butyl 12-aMino-4,7,10-trioxa-dodec
CAS:	252881-74-6
MF:	C13H27NO5
MW:	277.36
EINECS:
Product Categories:	PEG-COOtBu;peg
Mol File:	252881-74-6.mol

TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Chemical Properties

Boiling point	358.5±27.0 °C(Predicted)
density	1.029±0.06 g/cm3(Predicted)
Fp	169.7 °C
storage temp.	-20°C
pka	8.74±0.10(Predicted)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
WGK Germany	3
F	10-34
HS Code	2922500090

MSDS Information

TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Usage And Synthesis

Description

Amino-PEG3-t-butyl ester is a PEG linker containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry. Some of its applications are:

Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.
Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.
Synthesis of polycationic adamantane-based dendrons for cell imaging.
Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).

TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Preparation Products And Raw materials

Preparation Products

Maleimido-Tri(Ethylene Glycol)-Propionic Acid

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