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| Levocetirizine dihydrochloride Basic information |
| Levocetirizine dihydrochloride Chemical Properties |
| Melting point | 215-220°C | | alpha | D25 -12.79° (c = 1 in water) | | storage temp. | room temp | | solubility | H2O: ≥23mg/mL | | form | powder | | color | White to Almost white | | Merck | 14,2022 | | CAS DataBase Reference | 130018-87-0(CAS DataBase Reference) |
| Hazard Codes | Xn,N | | Risk Statements | 22-50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | RTECS | AG0990000 | | HS Code | 29335990 |
| Levocetirizine dihydrochloride Usage And Synthesis |
| Uses | Anti Histaminic | | Uses | Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis. | | General Description | Levocetirizine dihydrochloride,(R)-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride, (Xyzal) is awhite, crystalline powder and is water soluble. ThisR-enantiomer is has a 30-fold higher affinity than the S-enantiomer,and dissociates more slowly from H1-receptors.Pharmacologically, it displays the same receptor and CNSselecitivity profile as the racemate, cetirizine,and thus the same therapeutic advantages. Levocetirizine isindicated for the relief of symptoms associated with allergicrhinitis (seasonal and perennial) in adults and children 6 yearsof age and older and for the treatment of the uncomplicatedskin manifestations of chronic idiopathic urticaria in adultsand children 6 years of age and older. Its pharmacokineticsand clearance profile are essentially the same as the racemate,cetirizine . | | Biochem/physiol Actions | Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor. |
| Levocetirizine dihydrochloride Preparation Products And Raw materials |
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