2-Fluoro-5-nitrobenzoic acid

2-Fluoro-5-nitrobenzoic acid
  • CAS No.:7304-32-7
Other grades of this product :
2-Fluoro-5-nitrobenzoic acid Basic information
Product Name:2-Fluoro-5-nitrobenzoic acid
Synonyms:2-FLUORO-5-NITROBENZOIC ACID;RARECHEM AL BO 0445;BUTTPARK 32\01-76;2-Fluoro-5-nitrobenzoic acid 98%;2-Fluoro-5-nitrobenzoicacid98%;2-FLUORO-5-NITRROBENZOIC ACID;2-Fluoro-5-nitrobenzotc acid;NSC 133450
CAS:7304-32-7
MF:C7H4FNO4
MW:185.11
EINECS:627-772-7
Product Categories:Aromatics;Miscellaneous Reagents;C7;Carbonyl Compounds;Carboxylic Acids;Benzoic acid series;Fluorobenzene;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Fluorobenzoic acids
Mol File:7304-32-7.mol
2-Fluoro-5-nitrobenzoic acid Chemical Properties
Melting point 142-144 °C (lit.)
Boiling point 337.7±27.0 °C(Predicted)
density 1.568±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in chloroform, ethanol.
pka2.54±0.10(Predicted)
form Crystalline Powder
color White to pale yellow
BRN 1912835
CAS DataBase Reference7304-32-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HazardClass IRRITANT
HS Code 29163990
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
2-Fluoro-5-nitrobenzoic acid Usage And Synthesis
Chemical Propertieswhite to light yellow crystal powder
Uses2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support, synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols, in the synthesis of oxazepines.
Uses2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of:
  • dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (SNAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support
  • synthesis of substituted dibenzazocines on solid support, via SNAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols
  • in the synthesis of oxazepines
General Description2-Fluoro-5-nitrobenzoic acid is reported to react with an aldehyde, isonitrile and a primary amine tethered to a Boc-protected internal amino or hydroxyl nucleophile, to afford the Ugi product.
2-Fluoro-5-nitrobenzoic acid Preparation Products And Raw materials
Raw materials2-FLUORO-3-NITROBENZOIC ACID-->2-Fluorobenzoic acid-->2-Fluorotoluene-->Nitric acid
Preparation ProductsMETHYL 2-FLUORO-5-NITROBENZOATE

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