N-Formylpiperidine

CAS No.：2591-86-8

Other grades of this product :

N-Formylpiperidine Basic information

Product Name:	N-Formylpiperidine
Synonyms:	1-formyl-piperidin;1-Piperidinecarbaldehyde;N-Formylpiperdine;N-Formylpiperidin;1-Formylpiperidine,99%;N-Carbaldehyde piperidine;N-Formylpiperidine for synthesis;N-ForMylpiperidine, 99% 250ML
CAS:	2591-86-8
MF:	C6H11NO
MW:	113.16
EINECS:	219-986-0
Product Categories:	Piperidine
Mol File:	2591-86-8.mol

N-Formylpiperidine Chemical Properties

Melting point	-31 °C
Boiling point	222 °C(lit.)
density	1.019 g/mL at 25 °C(lit.)
vapor pressure	0.1 mm Hg ( 25 °C)
refractive index	n20/D 1.484(lit.)
Fp	197 °F
storage temp.	Store below +30°C.
form	Liquid
pka	-0.44±0.20(Predicted)
Specific Gravity	1.02
color	Clear colorless to slightly yellow
Water Solubility	freely soluble
BRN	107697
CAS DataBase Reference	2591-86-8(CAS DataBase Reference)
NIST Chemistry Reference	1-Piperidinecarboxaldehyde(2591-86-8)
EPA Substance Registry System	N-Formylpiperidine (2591-86-8)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	21/22-36/37/38
Safety Statements	26-36/37-36
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
RTECS	TN0380000
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	29333999

MSDS Information

Provider	Language
N-Formylpiperidine	English
SigmaAldrich	English
ACROS	English
ALFA	English

N-Formylpiperidine Usage And Synthesis

Description	This simple piperidine base has recently been discovered in the oxygenated fraction from Piper nigrum. The structure has been elucidated from chemical and spectroscopic data.
Chemical Properties	CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID
Uses	Solvent for polar and nonpolar compounds, as well as many high polymers; gas absorption; plastics modifiers.
Uses	Reactant for: Direct amidation of azoles with formamides via metal-free C-H activation in the presence of tert-butyl perbenzoate Vilsmeier-type reactions of pyrazoles with amides in the presence of phosphorous oxychloride CO-free aminocarbonylation of N-substituted formamides with aryl iodides/bromides catalyzed by palladium acetate and Xantphos for synthesis of arylamides Synthesis of alternating copolymers for organic photovoltaic applications One-pot double functionalization of π-deficient heterocyclic lithium reagents Synthesis of thermally stable piezofluorochromic aggregation-induced emission compounds
Synthesis Reference(s)	Chemical and Pharmaceutical Bulletin, 42, p. 1655, 1994 DOI: 10.1248/cpb.42.1655Synthetic Communications, 20, p. 447, 1990 DOI: 10.1080/00397919008052787
References	Debrauwere, Verzale, Bull. Soc. Chim. Belg., 84, 167 (1975)

N-Formylpiperidine Preparation Products And Raw materials

Raw materials	1-Isobutenylpiperidine-->1,1-Diphenylethane-->Fenpiprane-->1,1-Diphenylethylene-->Piperidine hydrochloride-->FORMANILIDE
Preparation Products	TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE-->5-BROMO-2-FLUOROPYRIDINE-3-CARBALDEHYDE-->1,3,5-Tris(p-formylphenyl)benzene-->3-Chloro-4-Cyanobenzaldehyde-->1-Tritylimidazole-4-carboxaldehyde-->4-Isobutylbenzaldehyde-->6-Hydroxy-2-naphthaldehyde-->5-FORMYL-2,4-DIMETHOXYPYRIMIDINE

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