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| 5-Hydroxyindole Basic information |
| 5-Hydroxyindole Chemical Properties |
| Melting point | 106-108 °C(lit.) | | Boiling point | 245.66°C (rough estimate) | | density | 1.1475 (rough estimate) | | refractive index | 1.5260 (estimate) | | storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C | | solubility | 38g/l | | form | Crystalline Needles or Powder | | pka | 9.98±0.40(Predicted) | | color | beige | | Sensitive | Light Sensitive | | BRN | 112349 | | CAS DataBase Reference | 1953-54-4(CAS DataBase Reference) | | NIST Chemistry Reference | Indol-5-ol(1953-54-4) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | RTECS | NM2430000 | | HazardClass | IRRITANT, KEEP COLD | | HS Code | 29339990 |
| 5-Hydroxyindole Usage And Synthesis |
| Chemical Properties | beige to brown crystalline needles or powder | | Uses | • ;Reactant for preparation of (oxoimidazolidinyl/oxopyrimidinyl)benzenesulfonates as antitumor agents and tubulin inhibitors1• ;Reactant for preparation of anthranilic acids2• ;Reactant for preparation of indole compounds as dopamine D2 receptor antagonists3• ;Reactant for preparation of naphthalimide- or carbazole-containing human β-adrenoceptor ligands4• ;Reactant for preparation of melanins as nature-inspired radioprotectors5• ;Reactant for preparation of 5-vinyl-3-pyridinecarbonitriles as PKCθ inhibitors6 | | Uses | 5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptop
han (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets. | | Uses | 5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptophan (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets. | | Synthesis Reference(s) | Journal of the American Chemical Society, 76, p. 5579, 1954 DOI: 10.1021/ja01651a001The Journal of Organic Chemistry, 49, p. 4833, 1984 DOI: 10.1021/jo00199a017 |
| 5-Hydroxyindole Preparation Products And Raw materials |
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