N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine

N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
  • CAS No.:309-88-6
Other grades of this product :
N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Basic information
Product Name:N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine
Synonyms:SHIKAWA'S REAGENT;N,N-DIETHYL-1,1,2,3,3,3-HEXAFLUOROPROPYLAMINE;Ishikawa's Reagent, 1-(Diethylamino)-1,1,2,3,3,3-hexafluoropropane;N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine, 40% solution in THF;Ishikawa;Ishikawa's Reagent, technical, 90%;Ishikawa Reagent;MEC-81
CAS:309-88-6
MF:C7H11F6N
MW:223.16
EINECS:628-698-8
Product Categories:Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Fluorination;Halogenation;Synthetic Organic Chemistry;Chemical Synthesis;Fluorination Reagents;Synthetic Reagents
Mol File:309-88-6.mol
N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Chemical Properties
Boiling point 56-57 °C (lit.)
density 1.230 g/mL at 25 °C (lit.)
refractive index 1.3460
Fp 56-57°C/58mm
storage temp. Flammables area
solubility soluble in Acetone,Ether
pka1.50±0.70(Predicted)
form Liquid
color Clear colorless to yellow
Specific Gravity1.230
Merck 14,5108
CAS DataBase Reference309-88-6(CAS DataBase Reference)
EPA Substance Registry SystemN,N-Diethyl-2H-perfluoropropanamine (309-88-6)
Safety Information
Hazard Codes C
Risk Statements 10-34
Safety Statements 16-26-36/37/39-45
RIDADR 3267
WGK Germany 3
Hazard Note Corrosive
HazardClass 8
PackingGroup II
HS Code 29211999
MSDS Information
ProviderLanguage
N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine English
ALFA English
N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Usage And Synthesis
Chemical PropertiesClear colorless to yellow liquid
UsesDemonstrates utility in fluorination.7
UsesFluorinating agent.
UsesReactant for:
  • Friedel-Crafts type arylation of hydrofluorocarbons
  • Microbial hydroxylation of antibiotics
  • Electrochemical fluorination of trialkylamines and tetraalkylammonium salts
  • Fluorination of pyrethroides
Reactant for synthesis of:
  • γ-Hydroxy-α-fluoro-α-trifluoromethylcarboxamide
  • Florfenicol and thiamphenicol
General DescriptionGC analysis includes Et2NCF=CFCF3 (two isomers), both of which are active fluorinating agents.
N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine Preparation Products And Raw materials
Raw materials1-Propen-1-amine, N,N-diethyl-1,2,3,3,3-pentafluoro--->N,N-DIETHYL-2,3,3,3-TETRAFLUOROPROPIONAMIDE-->1,2-DIBROMOHEXAFLUOROPROPANE-->Diethylamine-->Hexafluoropropylene

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