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| 4-Hydroxybenzophenone Basic information |
| 4-Hydroxybenzophenone Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36/37-24/25-36 | | WGK Germany | 2 | | RTECS | PC4959775 | | Hazard Note | Irritant | | TSCA | Yes | | HS Code | 29145000 |
| 4-Hydroxybenzophenone Usage And Synthesis |
| Chemical Properties | white to beige fine crystalline powder | | Uses | Metabolite of benzophenone. | | Uses | 4-Hydroxybenzophenone is used in the field of organic synthesis. It is used as pharmaceutical intermediate of clomifene citrate. | | Preparation | Preparation by condensation of benzotrichloride, ? with phenol in the presence of aluminium chloride in carbon disulfide at 0° (90%) or in the presence of zinc oxide in a water bath; ? with p-bromophenol in 30% sodium hydroxide solution at 80–85° (81%). There is substitution of the bromine atom by the benzoyl group. | | Synthesis Reference(s) | Journal of the American Chemical Society, 77, p. 4674, 1955 DOI: 10.1021/ja01622a074The Journal of Organic Chemistry, 19, p. 978, 1954 DOI: 10.1021/jo01371a016Tetrahedron Letters, 31, p. 3943, 1990 DOI: 10.1016/S0040-4039(00)97513-0 | | Flammability and Explosibility | Notclassified | | Purification Methods | Dissolve p-benzoylphenol in hot EtOH (charcoal), filter and cool. Alternatively crystallise it once from EtOH/H2O and twice from *benzene [Grunwald J Am Chem Soc 73 4934 1951, Dryland & Sheppard J Chem Soc Perkin Trans 1 125 1986]. [Beilstein 8 IV 1263.] |
| 4-Hydroxybenzophenone Preparation Products And Raw materials |
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