Other grades of this product :
| GSK-2126458 Basic information |
| GSK-2126458 Chemical Properties |
| Melting point | 187-189℃ | | Boiling point | 715.6±70.0 °C(Predicted) | | density | 1.45 | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated) | | form | Solid | | pka | 6.23±0.40(Predicted) | | color | White to Pale Yellow |
| GSK-2126458 Usage And Synthesis |
| Description | GSK2126458 is a potent inhibitor of phosphoinositide 3-kinase isoforms (Kis = 19, 130, 24, and 60 pM for p110α, β, δ, and γ, respectively). It also inhibits mTOR in both mTORC1 and mTORC2 (Kis = 180 and 300 nM, respectively), as well as several common mutant forms of p110α. GSK2126458 is orally bioavailable, displays favorable pharmacokinetics, and shows efficacy in tumor growth models. GSK2126458 positively combines with inhibitors of discoidin domain receptor 1 (DDR1) inhibitor DDR1-IN-1 to suppress the growth of SNU-1040 colorectal cancer cells. | | Uses | A highly potent inhibitor of PI3K and the mammalian target of Rapamycin. |
| GSK-2126458 Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye