Other grades of this product :
| DG 051 (HCl salt) Basic information |
| Product Name: | DG 051 (HCl salt) | | Synonyms: | DG 051 (HCl salt);4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride;DG051;(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride;DG051
(DG-051 | | CAS: | 929915-58-2 | | MF: | C21H25Cl2NO4 | | MW: | 426.3335 | | EINECS: | | Product Categories: | | Mol File: | 929915-58-2.mol |
| DG 051 (HCl salt) Chemical Properties |
| DG 051 (HCl salt) Usage And Synthesis |
| Description | DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 . However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; ), respectively, potentially leading to PGP accumulation in vivo. DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG. | | Uses | (2S)?-2-?[[4-?(4-Chlorophenoxy)?phenoxy]?methyl]?-1-?pyrrolidinebutanoic Acid Hydrochloride is a potent inhibitor leukotriene A4 hydrolase (LTA4H), which is a therapeutic target for developing treatments for cardiovascular diseases and cancers. |
| DG 051 (HCl salt) Preparation Products And Raw materials |
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