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| EGT1442 Basic information |
| Product Name: | EGT1442 | | Synonyms: | EGT1442;(1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-D-glucitol;Bexagliflozin;EGT1442(Bexagliflozin,THR1442);Bexagliflozin，EGT1442;CS-2165;EGT 0001442;EGT0001442 | | CAS: | 1118567-05-7 | | MF: | C24H29ClO7 | | MW: | 464.94 | | EINECS: | | Product Categories: | | Mol File: | 1118567-05-7.mol |
| EGT1442 Chemical Properties |
| Boiling point | 671.0±55.0 °C(Predicted) | | density | 1.41 | | pka | 13.23±0.70(Predicted) |
| EGT1442 Usage And Synthesis |
| Description | EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively. It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner. | | Uses | Bexagliflozin, also known as EGT1442, is a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients. |
| EGT1442 Preparation Products And Raw materials |
| Raw materials | Ethanol, 2-(cyclopropyloxy)-, 4-methylbenzenesulfonate
-->2-(2-Bromoethyl)-1,3-dioxolane-->(3R,4S,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol-->((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate-->4-broMo-1-chloro-2-(4-(2-cyclopropoxyethoxy)benzyl)benzene-->5-bromo-2-chloro-4’-ethoxydiphenylmethane-->4-(5-broMo-2-chlorobenzyl)phenol-->5-Bromo-2-chlorobenzoic acid-->D-(+)-Glucono-1,5-lactone |
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