| PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Basic information |
| Product Name: | PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE |
| Synonyms: | 2-Isoniazid Impurity;AKOS B014996;AKOS BBS-00004147;2-PICOLINYL HYDRAZIDE;ART-CHEM-BB B014996;PYRIDINE-2-CARBOHYDRAZIDE;PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE;2-pyridinecarboxylic acid hydrazide |
| CAS: | 1452-63-7 |
| MF: | C6H7N3O |
| MW: | 137.14 |
| EINECS: | |
| Product Categories: | Amines, Aromatics, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Amines;Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;AMIDE |
| Mol File: | 1452-63-7.mol |
| PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Chemical Properties |
| Melting point | 100°C |
| density | 1.244 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 11.29±0.10(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 1452-63-7(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 26-36/37/39-24/25 |
| HazardClass | IRRITANT |
| HS Code | 29333990 |
| MSDS Information |
| PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Usage And Synthesis |
| Chemical Properties | White to off-white solid |
| Uses | Pyridine-2-carboxylic acid hydrazide is an impurity of Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis and inhibits mycolic acid biosynthesis. Intermediate used for the synthesis of analogs of antitumor agent 1-acetyl-2-picolinoylhydrazine. |
| PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Preparation Products And Raw materials |
| Raw materials | Ethyl acetate-->Methanol-->Dichloromethane-->Thionyl chloride-->Hydrazinium hydroxide solution-->2-Picolinic acid |
| Preparation Products | 3-(2-PYRIDYL)-5,6-DIPHENYL-1,2,4-TRIAZINE |
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