Other grades of this product :
| Dropropizine Basic information |
| Dropropizine Chemical Properties |
| Melting point | 105° (Morren); mp 108° (Bourdais) | | Boiling point | 205 °C(Press: 1 Torr) | | density | 1.168±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | pka | 14.21±0.20(Predicted) | | form | neat | | color | White to Off-White | | CAS DataBase Reference | 17692-31-8(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | TZ1074800 | | Toxicity | LD50 in rats (mg/kg): 200 i.v., 750 orally (Morren) |
| Dropropizine Usage And Synthesis |
| Originator | Ribex,Formenti | | Uses | antitussive | | Uses | Dropropizine is a cough suppressant and central sedative therapeutic agent. | | Manufacturing Process | 34 g 1,2-epoxy-3-hydroxypropane (glycide) in 50 ml of water were added to
64.8 g 1-phenylpiperazine in 80 ml of ethanol at the temperature not higher
50°C. The mixture was stood at night, then it was evaporated to dryness in
vacuum and the stark product was recrystallized from 100 ml of acetone to
give 60 g 1-phenyl-4-(2,3-dihydroxypropyl)piperazine (dropropizine) MP
105°C; BP 205°C/1 mm Hg. | | Therapeutic Function | Antitussive |
| Dropropizine Preparation Products And Raw materials |
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