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| 1-Acetylimidazole Basic information |
| 1-Acetylimidazole Chemical Properties |
| Melting point | 99-105 °C (lit.) | | Boiling point | 206.4°C (rough estimate) | | density | 1.2111 (rough estimate) | | refractive index | 1.4800 (estimate) | | storage temp. | 2-8°C | | solubility | water: soluble50mg/mL, clear, colorless | | pka | pKa 3.6(H2O,t = 25,I=0.2) (Uncertain) | | form | Adhering Crystals or Crystalline Powder | | color | White to beige or light tan | | Water Solubility | Hydrolyzes in water. Solubility in methanol (almost transparency). | | Sensitive | Moisture Sensitive | | BRN | 108425 | | Stability: | Moisture Sensitive | | CAS DataBase Reference | 2466-76-4(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-Imidazole, 1-acetyl-(2466-76-4) | | EPA Substance Registry System | 1H-Imidazole, 1-acetyl- (2466-76-4) |
| Risk Statements | 36/37/38 | | Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | NI3400000 | | F | 10-21 | | TSCA | Yes | | HS Code | 29332900 |
| 1-Acetylimidazole Usage And Synthesis |
| Chemical Properties | white to beige or light tan adhering crystals or | | Uses | Acetylating agent for capping unreacted amino groups in peptide synthesis. | | Uses | It is a mild acylating agent and its reactivity can be enhanced by quaternization with, e.g. benzyl bromide. 1-Acetylimidazole was used as acetylation reagent for amino groups. It was also employed for acetylation of histones. It is relatively specific reagent for tyrosyl residue acetylatioa dn a reagent used in the synthesis of annulated imidazole derivatives. | | Uses | Relatively specific reagent for tyrosyl residue acetylation. Reagent used in the synthesis of annulated imidazole derivatives. | | General Description | Rate of solvolysis of 1-acetylimidazole in acid solutions was evaluated. Reaction of 1-acetylimidazole with orthophosphate and adenosine-5′-phosphate has been reported. | | Purification Methods | It is recrystallised from isopropenyl acetate and dried in a vacuum over P2O5. [Riordan & Valee Methods Enzymol 25 500 1972, Beilstein 23/4 V 218.] |
| 1-Acetylimidazole Preparation Products And Raw materials |
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