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| 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Basic information |
| Product Name: | 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID | | Synonyms: | 4H-thieno[3,2-b]pyrrole-5-carboxylic acid(SALTDATA: FREE);Thieno[2,3-b]pyrrole-5-carboxylic acid;4H-thieno[2,3-d]pyrrole-5-carboxylic acid;D-Amino Acid Oxidase Inhibitor;4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID;AKOS BB-9991;CHEMBRDG-BB 4012315;D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem | | CAS: | 39793-31-2 | | MF: | C7H5NO2S | | MW: | 167.19 | | EINECS: | | Product Categories: | | Mol File: | 39793-31-2.mol |
| 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Chemical Properties |
| Melting point | 180 °C | | density | 1.609 | | storage temp. | Sealed in dry,2-8°C | | form | Beige solid |
| 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Usage And Synthesis |
| Synthesis Reference(s) | Journal of the American Chemical Society, 79, p. 2556, 1957 DOI: 10.1021/ja01567a053 | | General Description | A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC50 against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC50 >5 μM), P450 enzymes CYP3A4/2D6/3C9 (IC50 >10 μM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects. |
| 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Preparation Products And Raw materials |
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![4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID](/img/39793-31-2.jpg "4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID")
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