trans-4-Hydroxy-L-proline methyl ester hydrochloride

CAS No.：40216-83-9

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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trans-4-Hydroxy-L-proline methyl ester hydrochloride Basic information

Product Name:	trans-4-Hydroxy-L-proline methyl ester hydrochloride
Synonyms:	H-HYP-OME HCL;H-L-HYP-OME HCL;HYDROXYPROLINE-OME HCL;(2S,4R)-trans-4-hydroxy-L-proline methyl ester hydrochloride;4-hydroxy-2-pyrrolidinecarboxylic acid methyl ester hydrochloride;L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE;L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT;L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE
CAS:	40216-83-9
MF:	C6H12ClNO3
MW:	181.62
EINECS:	609-795-4
Product Categories:	Peptide Synthesis;Proline Derivatives;Unnatural Amino Acid Derivatives;Amino Acids & Derivatives;Chiral Reagents;Heterocycles;Nitrogen cyclic compounds;Amino Acid Derivatives;Amino Acids;Hydroxyproline [Hyp]
Mol File:	40216-83-9.mol

trans-4-Hydroxy-L-proline methyl ester hydrochloride Chemical Properties

Melting point	169 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form	Solid
color	White to Off-White
BRN	4716932
Stability:	Hygroscopic
CAS DataBase Reference	40216-83-9(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Safety Statements	24/25
WGK Germany	3
HS Code	29339900

MSDS Information

trans-4-Hydroxy-L-proline methyl ester hydrochloride Usage And Synthesis

Chemical Properties	White Solid
Uses	trans-4-Hydroxy-L-proline (H952376) derivative. A natural constituent of animal structural proteins such as collagen and elastin.

trans-4-Hydroxy-L-proline methyl ester hydrochloride Preparation Products And Raw materials

Preparation Products

BOC-4-OXO-PRO-OME-->1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine-->N-BOC-cis-4-fluoro-L-proline

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