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| Ethyl 4'-hydroxy-3'-methoxycinnamate Basic information |
| Ethyl 4'-hydroxy-3'-methoxycinnamate Chemical Properties |
| Melting point | 63-65 °C(lit.) | | Boiling point | 164-166 °C0.5 mm Hg(lit.) | | density | 1.0643 (rough estimate) | | refractive index | 1.4560 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) | | form | Solid | | pka | 8.88±0.18(Predicted) | | color | White to Off-White | | Sensitive | Light Sensitive | | BRN | 2696807 | | Stability: | Hygroscopic, Light Sensitive | | InChIKey | ATJVZXXHKSYELS-FNORWQNLSA-N | | CAS DataBase Reference | 4046-02-0(CAS DataBase Reference) | | NIST Chemistry Reference | ethyl ferulate(4046-02-0) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29189900 |
| Ethyl 4'-hydroxy-3'-methoxycinnamate Usage And Synthesis |
| Description | Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes. Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging). However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide. Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70. | | Uses | Ferulic acid ethyl ester is an ethyl ester derivative of Ferulic acid (F308900), which is used as an antioxidant and food preservative. |
| Ethyl 4'-hydroxy-3'-methoxycinnamate Preparation Products And Raw materials |
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