Product

Ethyl 2-chloroacetoacetate

CAS No.：609-15-4

Other grades of this product :

Ethyl 2-chloroacetoacetate Basic information

Product Name:	Ethyl 2-chloroacetoacetate
Synonyms:	2-chloro-3-oxo-butanoicaciethylester;2-Chloro-3-oxobutyric acid ethyl ester;Acetoacetic acid, 2-chloro-, ethyl ester;Ethyl 2-chloracetoacetate;Ethyl 2-chloro-3-oxobutanoate;Oxiracetam Impurity 12;ETHYL 2-CHLOROACETOACETATE;ETHYL ALPHA-CHLOROACETOACETATE
CAS:	609-15-4
MF:	C6H9ClO3
MW:	164.59
EINECS:	210-180-4
Product Categories:	Organic synthesis;Aliphatics;Pharmaceutical Intermediates;C6 to C7;Carbonyl Compounds;Esters;Drug Intermediates;bc0001
Mol File:	609-15-4.mol

Ethyl 2-chloroacetoacetate Chemical Properties

Melting point	-80 °C
Boiling point	107 °C/14 mmHg (lit.)
density	1.19 g/mL at 25 °C (lit.)
vapor pressure	49.4-100Pa at 20℃
refractive index	n20/D 1.441(lit.)
Fp	122 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Liquid
pka	7.92±0.46(Predicted)
color	Clear yellow
Water Solubility	17 g/L (20 ºC)
BRN	774278
LogP	1.2 at 20℃ and pH1-7
Surface tension	69.4mN/m at 1g/L and 20℃
CAS DataBase Reference	609-15-4(CAS DataBase Reference)
NIST Chemistry Reference	Butanoic acid, 2-chloro-3-oxo-, ethyl ester(609-15-4)
EPA Substance Registry System	Ethyl 2-chloroacetoacetate (609-15-4)

Safety Information

Hazard Codes	C,Xn,F
Risk Statements	10-22-34-52/53-36/37/38-36
Safety Statements	16-26-36/37/39-45-61-37/39
RIDADR	UN 2920 8/PG 2
WGK Germany	2
F	19
Hazard Note	Corrosive
TSCA	Yes
HazardClass	3.2
PackingGroup	III
HS Code	29183000

MSDS Information

Provider	Language
2-Chloroacetoacetic acid ethyl ester	English
ACROS	English
SigmaAldrich	English
ALFA	English

Ethyl 2-chloroacetoacetate Usage And Synthesis

Chemical Properties	clear bright yellow liquid
Uses	Ethyl 2-chloroacetoacetate was used to study reductive dechlorination of β-keto ester ethyl 2-chloroacetoacetate by Saccharomyces cerevisiae.
Biochem/physiol Actions	Ethyl 2-chloroacetoacetate reacts with thiosemicarbazones to form heterocyclic substituted thiophene derivatives having non-steroidal anti-inflammatory activity.

Ethyl 2-chloroacetoacetate Preparation Products And Raw materials

Raw materials

Magnesium sulfate-->Ethyl acetoacetate-->Sulfuryl chloride-->2-CHLORO-3-OXO-BUTYRONITRILE-->Butanoic acid, 2-chloro-3-oxo--->Tosyl chloride-->Acetyl ketene-->Ethyl chloroacetate

Preparation Products

4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID-->4-METHYLOXAZOLE-5-CARBONYL CHLORIDE-->TERT-BUTYL 4-(5-FORMYL-4-METHYL-1,3-THIAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE-->2,4-Dimethylthiazole-5-carboxylic acid-->3,5-DIMETHYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER-->ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE-->4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBALDEHYDE-->4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE-->4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID-->Ethyl 2-amino-4-methylthiazole-5-carboxylate-->ETHYL 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLATE-->Methyl 2-chloroacetoacetate-->ethyl 2,4-dichloro-3-oxobutyrate-->Oxiracetam-->2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER

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