Girard's Reagent T

Girard's Reagent T
  • CAS No.:123-46-6
Other grades of this product :
Girard's Reagent T Basic information
Product Name:Girard's Reagent T
Synonyms:TRIMETHYLACETHYDRAZIDEAMMONIUM CHLORIDE;TRIMETHYLACETOHYDRAZIDEAMMONIUM CHLORIDE;(Carboxymethyl)trimethylammomiumchloridehydrazide;2-hydrazino-n,n,n-trimethyl-2-oxo-ethanaminiuchloride;LABOTEST-BB LT00455523;Betaine hydrazide hydrochloride~(Carboxymethyl)trimethylammonium chloride hydrazide;(2-Hydrazinyl-2-oxoethyl)-trimethylazanium chloride;(Trimethylaminio)acetic acid hydrazide·chloride
CAS:123-46-6
MF:C5H14N3O.Cl
MW:167.64
EINECS:204-629-3
Product Categories:Ammonium Chlorides (Quaternary);Quaternary Ammonium Compounds;Pharmaceutical Intermediates
Mol File:123-46-6.mol
Girard's Reagent T Chemical Properties
Melting point 188-192 °C (dec.) (lit.)
density 1.3799 (rough estimate)
refractive index 1.5400 (estimate)
storage temp. Inert atmosphere,Room Temperature
form powder to crystal
color White to Almost white
Water Solubility soluble
Merck 14,4429
BRN 3727163
CAS DataBase Reference123-46-6(CAS DataBase Reference)
EPA Substance Registry SystemEthanaminium, 2-hydrazino-N,N,N-trimethyl-2-oxo-, chloride (123-46-6)
Safety Information
Hazard Codes Xn-F,Xn,F
Risk Statements 44-36/37/38-20/22-11-R44-R36/37/38-R20/22-R11
Safety Statements 22-24/25-36/37/39-26-16-S36/37/39-S26-S16
WGK Germany 3
RTECS CP3150000
21
HS Code 29280000
MSDS Information
Girard's Reagent T Usage And Synthesis
Chemical Propertieswhite to almost white crystalline powder
UsesGirard''s Reagent T is a derivatizing agent used to generate permanent cationic charge at the reducing ends of neutral oligosaccharides for easier quantification in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).
UsesGirard′s reagent T may be used as a derivatizing reagent for the determination of 5-Formyl-2′-deoxyuridine in cellular DNA samples using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique. Reducing saccharides can be derivatized by Girard′s reagent T and this can be analyzed by matrix-assisted laser desorption/ionization coupled to time of flight mass spectrometry (MALDI-TOF-MS) technique.
Purification MethodsIt is purified by crystallisation from absolute EtOH (slight decomposition) until it has only a slight odour. Store it in well-stoppered containers because it is very hygroscopic. It is very soluble in H2O, AcOH and glycerol but slightly soluble in EtOH (0.66%). It forms water-soluble hydrazones with carbonyl compounds. [Beilstein 4 III 1133.]

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