4'-Methylbiphenyl-2-carboxylic acid

CAS No.：7148-03-0

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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4'-Methylbiphenyl-2-carboxylic acid Basic information

Product Name:	4'-Methylbiphenyl-2-carboxylic acid
Synonyms:	4'-METHYL[1,1'-BIPHENYL]-2-CARBOXYLIC ACID;2-(4-Methylphenyl)benzoic Acid 4'-Methylbiphenyl-2-carboxylic Acid;2-Carboxy-4'-methylbiphenyl, 2-(4-Methylphenyl)benzoic acid, 2-(p-Tolyl)benzoic acid;2-(p-Tolyl)benzoic Acid;1’-biphenyl]-2-carboxylicacid,4’-methyl-[;RARECHEM AL BO 0764;4'-Methyl-2-carboxybiphenyl;o-Tolylbenzoic acid
CAS:	7148-03-0
MF:	C14H12O2
MW:	212.24
EINECS:	230-462-0
Product Categories:	Organic acids;Hypertension;INTERMEDIATESOF;Biphenyl & Diphenyl ether;C13 to C42+;Carbonyl Compounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Carboxylic Acids
Mol File:	7148-03-0.mol

4'-Methylbiphenyl-2-carboxylic acid Chemical Properties

Melting point	146-148°C
Boiling point	354.5±11.0 °C(Predicted)
density	1.156±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO, Methanol
pka	3.90±0.36(Predicted)
form	Solid
color	White
CAS DataBase Reference	7148-03-0(CAS DataBase Reference)
EPA Substance Registry System	[1,1'-Biphenyl]-2-carboxylic acid, 4'-methyl- (7148-03-0)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
Hazard Note	Irritant
HS Code	29163990

MSDS Information

4'-Methylbiphenyl-2-carboxylic acid Usage And Synthesis

Chemical Properties	Light yellow solid
Uses	4’-Methylbiphenyl-2-carboxylic Acid is used in the synthesis of angiotensin II receptor antagonists used as potent orally active antihypertensives.
General Description	4′-Methyl-2-biphenylcarboxylic acid (4′-Methyl-bi-phenyl-2-carboxyl-ic acid) can be synthesized by reacting 4′-methylbiphenyl-2-carbonitrile with methanol and 30% NaOH solution. Its crystal structure has been characterized by the centrosymmetric hydrogen-bonded dimers.
Purification Methods	Crystallise the acid from toluene or *C6H6 (m 147-148o). [Beilstein 9 H 677, 9 IV 2523.]

4'-Methylbiphenyl-2-carboxylic acid Preparation Products And Raw materials

Preparation Products

Methyl 4'-methylbiphenyl-2-carboxylate-->4-BROMOMETHYLBIPHEBYL-2'-CARBOXYLIC ACID

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