trans-Methyl crotonate

CAS No.：623-43-8

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trans-Methyl crotonate Basic information

Synthesis

Product Name:	trans-Methyl crotonate
Synonyms:	METHYICROTONATE;trans-Methyl crotonate(E);Methyl crotonate ,99%;Methyl crotonate 1g [623-43-8];trans-Methyl crotonate, 98% 100GR;Methyl (E)-but-2-enoate;Methyl E-propene-1-carboxylate;trans-Methyl crotonate (E)-2-Butenoic acid methyl ester
CAS:	623-43-8
MF:	C5H8O2
MW:	100.12
EINECS:	210-793-7
Product Categories:	Fine Chemical;Building Blocks;C2 to C5;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;C2 to C5;Carbonyl Compounds;Esters
Mol File:	623-43-8.mol

trans-Methyl crotonate Chemical Properties

Melting point	-42°C
Boiling point	118-120 °C (lit.)
density	0.944 g/mL at 25 °C (lit.)
refractive index	n20/D 1.423(lit.)
Fp	40 °F
storage temp.	Flammables area
form	Liquid
color	Clear colorless
Water Solubility	IMMISCIBLE
Merck	14,2597
BRN	1720292
CAS DataBase Reference	623-43-8(CAS DataBase Reference)
NIST Chemistry Reference	2-Butenoic acid, methyl ester, (E)-(623-43-8)
EPA Substance Registry System	Methyl trans-crotonate (623-43-8)

Safety Information

Hazard Codes	F,Xi
Risk Statements	11-36/37/38
Safety Statements	16-26-36-9-33
RIDADR	UN 3272 3/PG 2
WGK Germany	2
RTECS	GQ5710000
TSCA	Yes
HazardClass	3
PackingGroup	II
HS Code	29161980

MSDS Information

Provider	Language
(E)-2-Butenoic acid methyl ester	English
ACROS	English
SigmaAldrich	English
ALFA	English

trans-Methyl crotonate Usage And Synthesis

Synthesis	Trans-Methyl crotonate is obtained by esterification of crotonic acid and methanol. The reaction solution prepared by 800g of crotonic acid, 1L of methanol, 130g of sulfuric acid and 300ml of carbon tetrachloride was heated on a water bath, and carbon tetrachloride was recovered after dehydration and esterification to obtain a crude product of methyl crotonate. Then, the unreacted crotonic acid in the crude product is washed with water, washed with 5% sodium carbonate, and purified by vacuum distillation to obtain the finished product.
Chemical Properties	CLEAR COLOURLESS LIQUID
Uses	Methyl crotonate was used to investigate chemo selectivity in the reaction between methyl crotonate and benzyl amine catalyzed by lipase B from Candida Antarctica using solvent engineering. It was used as starting reagent during the total synthesis of phytotoxins solanapyrones D(1) and E(2).
Synthesis Reference(s)	Tetrahedron Letters, 14, p. 2967, 1973 DOI: 10.1016/S0040-4039(01)96294-X
General Description	Methyl crotonate undergoes vinylogous aldol reaction with enolizable aldehydes in the presence of aluminum tris(2,6-di-2-naphthylphenoxide).

trans-Methyl crotonate Preparation Products And Raw materials

Raw materials	Carbon tetrachloride
Preparation Products	Cefaclor monohydrate-->Nicardipine-->Barnidipine-->2,4-DECADIENOIC ACID METHYL ESTER

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