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| 1,3-Difluorobenzene Chemical Properties |
| Melting point | -59 °C | | Boiling point | 83 °C | | density | 1.163 g/mL at 25 °C(lit.) | | vapor pressure | 11.034-19.924kPa at 20-38.2℃ | | refractive index | n20/D 1.438(lit.) | | Fp | 36 °F | | storage temp. | Flammables area | | solubility | 1.1g/l | | form | Liquid | | Specific Gravity | 1.163 | | color | Clear colorless to yellow | | Water Solubility | insoluble | | BRN | 1904537 | | LogP | 2.21-2.52 at 25℃ and pH6.5 | | CAS DataBase Reference | 372-18-9(CAS DataBase Reference) | | NIST Chemistry Reference | Benzene, 1,3-difluoro-(372-18-9) |
| Hazard Codes | F,Xn | | Risk Statements | 11-20-2017/11/20 | | Safety Statements | 7-16-29-33-7/9 | | RIDADR | UN 1993 3/PG 2 | | WGK Germany | 1 | | RTECS | CZ5652000 | | Hazard Note | Highly Flammable | | HazardClass | 3 | | PackingGroup | II | | HS Code | 29036990 |
| 1,3-Difluorobenzene Usage And Synthesis |
| Synthesis | Higher yields were observed when CsF and HF were reacted with 1,3-dichlorobenzene,
which gave I ,3-difluorobenzene. | | Chemical Properties | 1,3-Difluorobenzene (C6H4F2, CAS registry No. 372-18-9) is also named as m-difluorobenzene, which is a clear colorless to yellowish liquid. Its melting point is -59 °C, boiling point is 83 °C and flash point is 2 oC. It is insoluble in water and stable under normal temperatures and pressures. It is toxic and flammable. It will produce toxic fluoride gas by heat.
| | Uses | 1,3-Difluorobenzene has been extensively used in the synthesis of pharmaceutical and pesticide intermediate. For example, it can be used for the synthesis of fluorinated medicine such as Fluconazole, etc. and pesticide (Flucycloxuron, Diflubenzuro, etc.). It can also be used to synthesize liquid crystal materials.
| | Chemical Properties | CLEAR COLORLESS TO YELLOWISH LIQUID | | Uses | It is used in the laser induced fluorencence matrix study of 1,3-difluorobenzene radical cation. It is also used synthesis of 1,2,3-triazole containing fluconazole analogues. | | Definition | ChEBI: A difluorobenzene carrying fluoro groups at positions 1 and 3. |
| 1,3-Difluorobenzene Preparation Products And Raw materials |
| Raw materials | Hydrochloric acid-->Sodium nitrite-->Fluoroboric acid-->m-Phenylenediamine-->3-Nitroaniline-->Benzene, 1,3-difluoro-2-(triMethylsilyl)--->2,6-Difluoronitrobenzene-->2,4-Difluorophenylboronic acid-->2,4-Difluorobenzotrifluoride | | Preparation Products | Fluconazole-->6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole-->2,6-Difluorophenol-->Risperidone-->1-Bromo-2,4-difluorobenzene-->2,4-Difluoronitrobenzene-->3,5-Difluorobenzoic acid-->3-(2',4'-DIFLUOROPHENYL)-3-OXOPROPANENITRILE-->2,4-Difluorophenylacetic acid-->6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride-->2',4'-Difluoroacetophenone-->3-FLUOROBENZYLOXYBENZENE-->1,3-PROPANEDIOL, 2-[2-(2,4-DIFLUOROPHENYL)-2-PROPEN-1-YL]- |
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